Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149274904> ?p ?o ?g. }
- W2149274904 endingPage "1322" @default.
- W2149274904 startingPage "1316" @default.
- W2149274904 abstract "Signaling cascades initiated by Wnt lipoglycoproteins and their receptors of the Frizzled family regulate many aspects of animal development and physiology. Improper activation of this signaling promotes carcinogenic transformation and metastasis. Development of agents blocking the Wnt-Frizzled signaling is of prime interest for drug discovery. Despite certain progress no such agents are as yet brought to the market or even to clinical trials. One reason for these delays might be the use of suboptimal readout assays. In this article we overview existing and developing assay platforms to screen for Wnt-Frizzled antagonists. Among those, G protein-activating assays built on the emerging GPCR properties of Frizzleds are highlighted." @default.
- W2149274904 created "2016-06-24" @default.
- W2149274904 creator A5038733212 @default.
- W2149274904 creator A5087206207 @default.
- W2149274904 date "2012-12-01" @default.
- W2149274904 modified "2023-10-18" @default.
- W2149274904 title "Platforms for high-throughput screening of Wnt/Frizzled antagonists" @default.
- W2149274904 cites W1517339234 @default.
- W2149274904 cites W1535424359 @default.
- W2149274904 cites W1549691444 @default.
- W2149274904 cites W1580526178 @default.
- W2149274904 cites W1606541986 @default.
- W2149274904 cites W1968064237 @default.
- W2149274904 cites W1969534054 @default.
- W2149274904 cites W1980762084 @default.
- W2149274904 cites W1981385111 @default.
- W2149274904 cites W1992465003 @default.
- W2149274904 cites W1998493765 @default.
- W2149274904 cites W2005440429 @default.
- W2149274904 cites W2006940769 @default.
- W2149274904 cites W2007948112 @default.
- W2149274904 cites W2008956402 @default.
- W2149274904 cites W2011366619 @default.
- W2149274904 cites W2011964198 @default.
- W2149274904 cites W2013647364 @default.
- W2149274904 cites W2015296123 @default.
- W2149274904 cites W2022389224 @default.
- W2149274904 cites W2027078627 @default.
- W2149274904 cites W2032465593 @default.
- W2149274904 cites W2035192365 @default.
- W2149274904 cites W2039435520 @default.
- W2149274904 cites W2039654095 @default.
- W2149274904 cites W2055716317 @default.
- W2149274904 cites W2057257265 @default.
- W2149274904 cites W2057842092 @default.
- W2149274904 cites W2059908281 @default.
- W2149274904 cites W2063106746 @default.
- W2149274904 cites W2065914048 @default.
- W2149274904 cites W2066251900 @default.
- W2149274904 cites W2066583853 @default.
- W2149274904 cites W2068009069 @default.
- W2149274904 cites W2070524062 @default.
- W2149274904 cites W2072008436 @default.
- W2149274904 cites W2073423527 @default.
- W2149274904 cites W2074069995 @default.
- W2149274904 cites W2079771195 @default.
- W2149274904 cites W2084771679 @default.
- W2149274904 cites W2087610808 @default.
- W2149274904 cites W2088139400 @default.
- W2149274904 cites W2088942336 @default.
- W2149274904 cites W2093256612 @default.
- W2149274904 cites W2097689792 @default.
- W2149274904 cites W2105852442 @default.
- W2149274904 cites W2105953048 @default.
- W2149274904 cites W2107420053 @default.
- W2149274904 cites W2108981830 @default.
- W2149274904 cites W2112109310 @default.
- W2149274904 cites W2113263838 @default.
- W2149274904 cites W2114867213 @default.
- W2149274904 cites W2114946540 @default.
- W2149274904 cites W2119284420 @default.
- W2149274904 cites W2119780609 @default.
- W2149274904 cites W2124682830 @default.
- W2149274904 cites W2125692373 @default.
- W2149274904 cites W2128918732 @default.
- W2149274904 cites W2129354010 @default.
- W2149274904 cites W2134597651 @default.
- W2149274904 cites W2140154776 @default.
- W2149274904 cites W2140594014 @default.
- W2149274904 cites W2145493641 @default.
- W2149274904 cites W2153803455 @default.
- W2149274904 cites W2155847232 @default.
- W2149274904 cites W2162564067 @default.
- W2149274904 cites W2166296674 @default.
- W2149274904 cites W2167638513 @default.
- W2149274904 cites W2170494228 @default.
- W2149274904 cites W2171204703 @default.
- W2149274904 cites W4231585884 @default.
- W2149274904 doi "https://doi.org/10.1016/j.drudis.2012.07.007" @default.
- W2149274904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22819927" @default.
- W2149274904 hasPublicationYear "2012" @default.
- W2149274904 type Work @default.
- W2149274904 sameAs 2149274904 @default.
- W2149274904 citedByCount "28" @default.
- W2149274904 countsByYear W21492749042014 @default.
- W2149274904 countsByYear W21492749042015 @default.
- W2149274904 countsByYear W21492749042016 @default.
- W2149274904 countsByYear W21492749042017 @default.
- W2149274904 countsByYear W21492749042018 @default.
- W2149274904 countsByYear W21492749042019 @default.
- W2149274904 countsByYear W21492749042020 @default.
- W2149274904 countsByYear W21492749042021 @default.
- W2149274904 countsByYear W21492749042022 @default.
- W2149274904 countsByYear W21492749042023 @default.
- W2149274904 crossrefType "journal-article" @default.
- W2149274904 hasAuthorship W2149274904A5038733212 @default.
- W2149274904 hasAuthorship W2149274904A5087206207 @default.
- W2149274904 hasBestOaLocation W21492749042 @default.