Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149282572> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2149282572 endingPage "3011" @default.
- W2149282572 startingPage "3011" @default.
- W2149282572 abstract "Drug delivery via the sclera is a promising approach to retinal disorder treatments that require access to the posterior segment of the eye. To complement existing studies of transverse diffusion across the sclera, this study examined lateral diffusion within the sclera parallel to the scleral surface.Using sulforhodamine as a model hydrophilic drug, rates of diffusion were measured in strips of human cadaveric sclera for up to 1 week. Data were analyzed with a mathematical model based on theoretical expressions for one-dimensional diffusion.Measurable amounts of sulforhodamine were detected at distances of 5 and 10 mm from the sulforhodamine donor reservoir at 4 hours and 3 days, respectively. The effective lateral diffusivity of sulforhodamine was determined to be 3.82 x 10(-6) cm2/s, which is similar in magnitude to the transverse diffusivity. The theoretical model agreed with experimental values with an average error of 39%.This study shows that the lateral diffusion of sulforhodamine in human sclera is slow and localizes to the site of administration." @default.
- W2149282572 created "2016-06-24" @default.
- W2149282572 creator A5028629747 @default.
- W2149282572 creator A5030894404 @default.
- W2149282572 creator A5038576932 @default.
- W2149282572 creator A5083984022 @default.
- W2149282572 date "2006-07-01" @default.
- W2149282572 modified "2023-09-24" @default.
- W2149282572 title "Measurement and Prediction of Lateral Diffusion within Human Sclera" @default.
- W2149282572 cites W1568901762 @default.
- W2149282572 cites W1597285101 @default.
- W2149282572 cites W17499265 @default.
- W2149282572 cites W1986180285 @default.
- W2149282572 cites W1996540455 @default.
- W2149282572 cites W1996853317 @default.
- W2149282572 cites W1997156360 @default.
- W2149282572 cites W2024957445 @default.
- W2149282572 cites W2043928656 @default.
- W2149282572 cites W2059541476 @default.
- W2149282572 cites W2069557849 @default.
- W2149282572 cites W2077250374 @default.
- W2149282572 cites W2086373689 @default.
- W2149282572 cites W2971629176 @default.
- W2149282572 cites W46341933 @default.
- W2149282572 cites W59239023 @default.
- W2149282572 doi "https://doi.org/10.1167/iovs.05-1464" @default.
- W2149282572 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16799047" @default.
- W2149282572 hasPublicationYear "2006" @default.
- W2149282572 type Work @default.
- W2149282572 sameAs 2149282572 @default.
- W2149282572 citedByCount "17" @default.
- W2149282572 countsByYear W21492825722012 @default.
- W2149282572 countsByYear W21492825722013 @default.
- W2149282572 countsByYear W21492825722016 @default.
- W2149282572 countsByYear W21492825722017 @default.
- W2149282572 countsByYear W21492825722021 @default.
- W2149282572 countsByYear W21492825722022 @default.
- W2149282572 countsByYear W21492825722023 @default.
- W2149282572 crossrefType "journal-article" @default.
- W2149282572 hasAuthorship W2149282572A5028629747 @default.
- W2149282572 hasAuthorship W2149282572A5030894404 @default.
- W2149282572 hasAuthorship W2149282572A5038576932 @default.
- W2149282572 hasAuthorship W2149282572A5083984022 @default.
- W2149282572 hasBestOaLocation W21492825721 @default.
- W2149282572 hasConcept C109316439 @default.
- W2149282572 hasConcept C118487528 @default.
- W2149282572 hasConcept C121332964 @default.
- W2149282572 hasConcept C136229726 @default.
- W2149282572 hasConcept C185592680 @default.
- W2149282572 hasConcept C192562407 @default.
- W2149282572 hasConcept C202751555 @default.
- W2149282572 hasConcept C2776074239 @default.
- W2149282572 hasConcept C2777100477 @default.
- W2149282572 hasConcept C37668627 @default.
- W2149282572 hasConcept C55493867 @default.
- W2149282572 hasConcept C69357855 @default.
- W2149282572 hasConcept C71924100 @default.
- W2149282572 hasConcept C97355855 @default.
- W2149282572 hasConceptScore W2149282572C109316439 @default.
- W2149282572 hasConceptScore W2149282572C118487528 @default.
- W2149282572 hasConceptScore W2149282572C121332964 @default.
- W2149282572 hasConceptScore W2149282572C136229726 @default.
- W2149282572 hasConceptScore W2149282572C185592680 @default.
- W2149282572 hasConceptScore W2149282572C192562407 @default.
- W2149282572 hasConceptScore W2149282572C202751555 @default.
- W2149282572 hasConceptScore W2149282572C2776074239 @default.
- W2149282572 hasConceptScore W2149282572C2777100477 @default.
- W2149282572 hasConceptScore W2149282572C37668627 @default.
- W2149282572 hasConceptScore W2149282572C55493867 @default.
- W2149282572 hasConceptScore W2149282572C69357855 @default.
- W2149282572 hasConceptScore W2149282572C71924100 @default.
- W2149282572 hasConceptScore W2149282572C97355855 @default.
- W2149282572 hasIssue "7" @default.
- W2149282572 hasLocation W21492825721 @default.
- W2149282572 hasLocation W21492825722 @default.
- W2149282572 hasOpenAccess W2149282572 @default.
- W2149282572 hasPrimaryLocation W21492825721 @default.
- W2149282572 hasRelatedWork W1983385672 @default.
- W2149282572 hasRelatedWork W2048659695 @default.
- W2149282572 hasRelatedWork W2076178893 @default.
- W2149282572 hasRelatedWork W2149282572 @default.
- W2149282572 hasRelatedWork W2171733821 @default.
- W2149282572 hasRelatedWork W2221365989 @default.
- W2149282572 hasRelatedWork W2334447102 @default.
- W2149282572 hasRelatedWork W2378360900 @default.
- W2149282572 hasRelatedWork W2530171255 @default.
- W2149282572 hasRelatedWork W4214685150 @default.
- W2149282572 hasVolume "47" @default.
- W2149282572 isParatext "false" @default.
- W2149282572 isRetracted "false" @default.
- W2149282572 magId "2149282572" @default.
- W2149282572 workType "article" @default.