FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149282639> ?p ?o ?g. }

• W2149282639 endingPage "731" @default.
• W2149282639 startingPage "718" @default.
• W2149282639 abstract "Mitochondrial complex II is a tumor suppressor comprised of four subunits (SdhA, SdhB, SdhC, and SdhD). Mutations in any of these should disrupt complex II enzymatic activity, yet defects in SdhA produce bioenergetic deficiency while defects in SdhB, SdhC, or SdhD induce tumor formation. The mechanisms underlying these differences are not known. We show that the inhibition of distal subunits of complex II, either pharmacologically or via RNA interference of SdhB, increases normoxic reactive oxygen species (ROS) production, increases hypoxia-inducible factor alpha (HIF-α) stabilization in an ROS-dependent manner, and increases growth rates in vitro and in vivo without affecting hypoxia-mediated activation of HIF-α. Proximal pharmacologic inhibition or RNA interference of complex II at SdhA, however, does not increase normoxic ROS production or HIF-α stabilization and results in decreased growth rates in vitro and in vivo. Furthermore, the enhanced growth rates resulting from SdhB suppression are inhibited by the suppression of HIF-1α and/or HIF-2α, indicating that the mechanism of SdhB-induced tumor formation relies upon ROS production and subsequent HIF-α activation. Therefore, differences in ROS production, HIF proliferation, and cell proliferation contribute to the differences in tumor phenotype in cells lacking SdhB as opposed to those lacking SdhA." @default.
• W2149282639 created "2016-06-24" @default.
• W2149282639 creator A5045738532 @default.
• W2149282639 creator A5046518034 @default.
• W2149282639 creator A5062948558 @default.
• W2149282639 creator A5076543971 @default.
• W2149282639 creator A5081897750 @default.
• W2149282639 date "2008-01-01" @default.
• W2149282639 modified "2023-10-04" @default.
• W2149282639 title "Loss of the SdhB, but Not the SdhA, Subunit of Complex II Triggers Reactive Oxygen Species-Dependent Hypoxia-Inducible Factor Activation and Tumorigenesis" @default.
• W2149282639 cites W1488265246 @default.
• W2149282639 cites W1547863599 @default.
• W2149282639 cites W1965112488 @default.
• W2149282639 cites W1969931826 @default.
• W2149282639 cites W1970274697 @default.
• W2149282639 cites W1972889641 @default.
• W2149282639 cites W1972944556 @default.
• W2149282639 cites W1975918337 @default.
• W2149282639 cites W1976752846 @default.
• W2149282639 cites W1978916986 @default.
• W2149282639 cites W1984501829 @default.
• W2149282639 cites W1987400910 @default.
• W2149282639 cites W1991346678 @default.
• W2149282639 cites W1997076510 @default.
• W2149282639 cites W1997161797 @default.
• W2149282639 cites W2008506583 @default.
• W2149282639 cites W2017978798 @default.
• W2149282639 cites W2018884388 @default.
• W2149282639 cites W2020498032 @default.
• W2149282639 cites W2023172513 @default.
• W2149282639 cites W2023600189 @default.
• W2149282639 cites W2029155832 @default.
• W2149282639 cites W2037454422 @default.
• W2149282639 cites W2044412059 @default.
• W2149282639 cites W2044414180 @default.
• W2149282639 cites W2054115346 @default.
• W2149282639 cites W2057199368 @default.
• W2149282639 cites W2059643938 @default.
• W2149282639 cites W2059747280 @default.
• W2149282639 cites W2060363769 @default.
• W2149282639 cites W2060490290 @default.
• W2149282639 cites W2069271483 @default.
• W2149282639 cites W2070885735 @default.
• W2149282639 cites W2071045537 @default.
• W2149282639 cites W2085470258 @default.
• W2149282639 cites W2090226049 @default.
• W2149282639 cites W2093711185 @default.
• W2149282639 cites W2096318298 @default.
• W2149282639 cites W2112007824 @default.
• W2149282639 cites W2112438801 @default.
• W2149282639 cites W2113477380 @default.
• W2149282639 cites W2116622745 @default.
• W2149282639 cites W2126511952 @default.
• W2149282639 cites W2135414906 @default.
• W2149282639 cites W2136749294 @default.
• W2149282639 cites W2139250665 @default.
• W2149282639 cites W2143182501 @default.
• W2149282639 cites W2153948449 @default.
• W2149282639 cites W2161877652 @default.
• W2149282639 cites W2163267056 @default.
• W2149282639 cites W2164801924 @default.
• W2149282639 cites W2165623186 @default.
• W2149282639 cites W2169562930 @default.
• W2149282639 doi "https://doi.org/10.1128/mcb.01338-07" @default.
• W2149282639 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2223429" @default.
• W2149282639 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17967865" @default.
• W2149282639 hasPublicationYear "2008" @default.
• W2149282639 type Work @default.
• W2149282639 sameAs 2149282639 @default.
• W2149282639 citedByCount "371" @default.
• W2149282639 countsByYear W21492826392012 @default.
• W2149282639 countsByYear W21492826392013 @default.
• W2149282639 countsByYear W21492826392014 @default.
• W2149282639 countsByYear W21492826392015 @default.
• W2149282639 countsByYear W21492826392016 @default.
• W2149282639 countsByYear W21492826392017 @default.
• W2149282639 countsByYear W21492826392018 @default.
• W2149282639 countsByYear W21492826392019 @default.
• W2149282639 countsByYear W21492826392020 @default.
• W2149282639 countsByYear W21492826392021 @default.
• W2149282639 countsByYear W21492826392022 @default.
• W2149282639 countsByYear W21492826392023 @default.
• W2149282639 crossrefType "journal-article" @default.
• W2149282639 hasAuthorship W2149282639A5045738532 @default.
• W2149282639 hasAuthorship W2149282639A5046518034 @default.
• W2149282639 hasAuthorship W2149282639A5062948558 @default.
• W2149282639 hasAuthorship W2149282639A5076543971 @default.
• W2149282639 hasAuthorship W2149282639A5081897750 @default.
• W2149282639 hasBestOaLocation W21492826392 @default.
• W2149282639 hasConcept C104317684 @default.
• W2149282639 hasConcept C13514818 @default.
• W2149282639 hasConcept C2776453936 @default.
• W2149282639 hasConcept C2779620337 @default.
• W2149282639 hasConcept C2780744430 @default.
• W2149282639 hasConcept C2781330172 @default.
• W2149282639 hasConcept C28859421 @default.
• W2149282639 hasConcept C501734568 @default.
• W2149282639 hasConcept C502942594 @default.

• next