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• W2149288036 abstract "Nephrolithiasis in the Slc26a6 −/− mouse is accompanied by 50–75% reduction in intestinal oxalate secretion with unchanged intestinal oxalate absorption. The molecular identities of enterocyte pathways for oxalate absorption and for Slc26a6-independent oxalate secretion remain undefined. The reported intestinal expression of SO 4 2− transporter SLC26A2 prompted us to characterize transport of oxalate and other anions by human SLC26A2 and mouse Slc26a2 expressed in Xenopus oocytes. We found that hSLC26A2-mediated [ 14 C]oxalate uptake ( K 1/2 of 0.65 ± 0.08 mM) was cis-inhibited by external SO 4 2− ( K 1/2 of 3.1 mM). hSLC26A2-mediated bidirectional oxalate/SO 4 2− exchange exhibited extracellular SO 4 2− K 1/2 of 1.58 ± 0.44 mM for exchange with intracellular [ 14 C]oxalate, and extracellular oxalate K 1/2 of 0.14 ± 0.11 mM for exchange with intracellular 35 SO 4 2− . Influx rates and K 1/2 values for mSlc26a2 were similar. hSLC26A2-mediated oxalate/Cl − exchange and bidirectional SO 4 2− /Cl − exchange were not detectably electrogenic. Both SLC26A2 orthologs exhibited nonsaturable extracellular Cl − dependence for efflux of intracellular [ 14 C]oxalate, 35 SO 4 2− , or 36 Cl − . Rate constants for 36 Cl − efflux into extracellular Cl − , SO 4 2− , and oxalate were uniformly 10-fold lower than for oppositely directed exchange. Acidic extracellular pH (pH o ) inhibited all modes of hSLC26A2-mediated anion exchange. In contrast, acidic intracellular pH (pH i ) selectively activated exchange of extracellular Cl − for intracellular 35 SO 4 2− but not for intracellular 36 Cl − or [ 14 C]oxalate. Protein kinase C inhibited hSLC26A2 by reducing its surface abundance. Diastrophic dysplasia mutants R279W and A386V of hSLC26A2 exhibited similar reductions in uptake of both 35 SO 4 2− and [ 14 C]oxalate. A386V surface abundance was reduced, but R279W surface abundance was at wild-type levels." @default.
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• W2149288036 date "2010-06-01" @default.
• W2149288036 modified "2023-09-26" @default.
• W2149288036 title "Regulated transport of sulfate and oxalate by SLC26A2/DTDST" @default.
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• W2149288036 doi "https://doi.org/10.1152/ajpcell.00004.2010" @default.
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