FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149288519> ?p ?o ?g. }

• W2149288519 endingPage "804" @default.
• W2149288519 startingPage "798" @default.
• W2149288519 abstract "Abstract Drugs that elevate cAMP levels in human basophils are known to inhibit immunoglobulin E (IgE)-mediated histamine release. We have examined whether cAMP-active agents inhibit the cytosolic Ca2+, [Ca2+]i, response that normally accompanies activation of basophils. As previously described, this [Ca2+]i response is biphasic, one phase dependent on internal sources of calcium and a second later phase dependent on extracellular calcium, as observed in many cell types. Forskolin and rolipram or their combination had no effect on the initial elevation of cytosolic calcium that follows stimulation with anti-IgE antibody. In contrast, the second phase of the IgE-mediated calcium response was inhibited by these agents. For IgE-mediated responses, the relative efficacy of various cAMP active agents (rolipram forskolin &lt; dibutyryl cAMP &lt; forskolin + rolipram) for the inhibition of histamine release and the second-phase calcium response was similar and roughly paralleled the measured increase in basophil cAMP. In contrast, neither the first nor the second phase of the f-Met-Leu-Phe (fMLP)-induced calcium response was inhibited by any of the cAMP-active agents tested. Indeed, at low concentrations of fMLP, a combination of forskolin and rolipram caused slight enhancement of the calcium response. This result was consistent with the observations that these agents had no effect or caused slight enhancement of histamine or leukotriene released induced by fMLP. Similarly, cAMP-active agents caused no inhibition of C5a or phorbol ester (phorbol myristate acetate)-induced histamine release. These observations suggest that inhibition of the phase of the calcium response that is dependent on extracellular calcium could account for the inhibition of histamine release by these agents. However, these studies also suggested that (1) this is effect is not exerted at the level of the inositol trisphosphate (InsP3) receptor or InsP3 metabolism and (2) the mechanisms that maintain the second-phase calcium response are possibly distinct for IgE- and fMLP-mediated reactions because cAMP-active agents inhibited the second-phase response of only one stimulus. J. Leukoc. Biol. 55: 798–804; 1994." @default.
• W2149288519 created "2016-06-24" @default.
• W2149288519 creator A5029472044 @default.
• W2149288519 creator A5081046119 @default.
• W2149288519 date "1994-06-01" @default.
• W2149288519 modified "2023-10-18" @default.
• W2149288519 title "Differential effects of cAMP-elevating drugs on stimulus-induced cytosolic calcium changes in human basophils" @default.
• W2149288519 cites W1519541812 @default.
• W2149288519 cites W1522849919 @default.
• W2149288519 cites W1532402086 @default.
• W2149288519 cites W1535277645 @default.
• W2149288519 cites W1538224608 @default.
• W2149288519 cites W1546782115 @default.
• W2149288519 cites W1555189702 @default.
• W2149288519 cites W1558446989 @default.
• W2149288519 cites W1582349222 @default.
• W2149288519 cites W1597772434 @default.
• W2149288519 cites W1599196898 @default.
• W2149288519 cites W1602207835 @default.
• W2149288519 cites W1607010538 @default.
• W2149288519 cites W1646639774 @default.
• W2149288519 cites W1651229391 @default.
• W2149288519 cites W1901311222 @default.
• W2149288519 cites W1912839853 @default.
• W2149288519 cites W1966039400 @default.
• W2149288519 cites W1991276814 @default.
• W2149288519 cites W1998606603 @default.
• W2149288519 cites W2007432771 @default.
• W2149288519 cites W2021094409 @default.
• W2149288519 cites W2047316488 @default.
• W2149288519 cites W2052082098 @default.
• W2149288519 cites W2061014404 @default.
• W2149288519 cites W2069834296 @default.
• W2149288519 cites W2070832223 @default.
• W2149288519 cites W2071138461 @default.
• W2149288519 cites W2071331983 @default.
• W2149288519 cites W2087372862 @default.
• W2149288519 cites W2090334210 @default.
• W2149288519 cites W2091780008 @default.
• W2149288519 cites W2096637103 @default.
• W2149288519 cites W2140488772 @default.
• W2149288519 cites W2159868170 @default.
• W2149288519 cites W2182218622 @default.
• W2149288519 cites W2267451236 @default.
• W2149288519 cites W2281179837 @default.
• W2149288519 cites W4211131955 @default.
• W2149288519 doi "https://doi.org/10.1002/jlb.55.6.798" @default.
• W2149288519 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7515096" @default.
• W2149288519 hasPublicationYear "1994" @default.
• W2149288519 type Work @default.
• W2149288519 sameAs 2149288519 @default.
• W2149288519 citedByCount "23" @default.
• W2149288519 countsByYear W21492885192012 @default.
• W2149288519 countsByYear W21492885192014 @default.
• W2149288519 countsByYear W21492885192016 @default.
• W2149288519 crossrefType "journal-article" @default.
• W2149288519 hasAuthorship W2149288519A5029472044 @default.
• W2149288519 hasAuthorship W2149288519A5081046119 @default.
• W2149288519 hasConcept C1122143 @default.
• W2149288519 hasConcept C126322002 @default.
• W2149288519 hasConcept C134018914 @default.
• W2149288519 hasConcept C181199279 @default.
• W2149288519 hasConcept C185592680 @default.
• W2149288519 hasConcept C195794163 @default.
• W2149288519 hasConcept C24998067 @default.
• W2149288519 hasConcept C2776958096 @default.
• W2149288519 hasConcept C2779276759 @default.
• W2149288519 hasConcept C2780043322 @default.
• W2149288519 hasConcept C519063684 @default.
• W2149288519 hasConcept C55493867 @default.
• W2149288519 hasConcept C62826618 @default.
• W2149288519 hasConcept C71924100 @default.
• W2149288519 hasConcept C86803240 @default.
• W2149288519 hasConceptScore W2149288519C1122143 @default.
• W2149288519 hasConceptScore W2149288519C126322002 @default.
• W2149288519 hasConceptScore W2149288519C134018914 @default.
• W2149288519 hasConceptScore W2149288519C181199279 @default.
• W2149288519 hasConceptScore W2149288519C185592680 @default.
• W2149288519 hasConceptScore W2149288519C195794163 @default.
• W2149288519 hasConceptScore W2149288519C24998067 @default.
• W2149288519 hasConceptScore W2149288519C2776958096 @default.
• W2149288519 hasConceptScore W2149288519C2779276759 @default.
• W2149288519 hasConceptScore W2149288519C2780043322 @default.
• W2149288519 hasConceptScore W2149288519C519063684 @default.
• W2149288519 hasConceptScore W2149288519C55493867 @default.
• W2149288519 hasConceptScore W2149288519C62826618 @default.
• W2149288519 hasConceptScore W2149288519C71924100 @default.
• W2149288519 hasConceptScore W2149288519C86803240 @default.
• W2149288519 hasIssue "6" @default.
• W2149288519 hasLocation W21492885191 @default.
• W2149288519 hasLocation W21492885192 @default.
• W2149288519 hasOpenAccess W2149288519 @default.
• W2149288519 hasPrimaryLocation W21492885191 @default.
• W2149288519 hasRelatedWork W1975696001 @default.
• W2149288519 hasRelatedWork W1983315707 @default.
• W2149288519 hasRelatedWork W2007885146 @default.
• W2149288519 hasRelatedWork W2053936620 @default.
• W2149288519 hasRelatedWork W2054038633 @default.

• next