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• W2149291473 abstract "MicroRNAs (miRNAs), which function as regulators of gene expression in eukaryotes, are processed from larger transcripts by sequential action of nuclear and cytoplasmic ribonuclease III-like endonucleases. We show that Exportin-5 (Exp5) mediates efficient nuclear export of short miRNA precursors (pre-miRNAs) and that its depletion by RNA interference results in reduced miRNA levels. Exp5 binds correctly processed pre-miRNAs directly and specifically, in a Ran guanosine triphosphate-dependent manner, but interacts only weakly with extended pre-miRNAs that yield incorrect miRNAs when processed by Dicer in vitro. Thus, Exp5 is key to miRNA biogenesis and may help coordinate nuclear and cytoplasmic processing steps." @default.
• W2149291473 created "2016-06-24" @default.
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• W2149291473 date "2004-01-02" @default.
• W2149291473 modified "2023-10-16" @default.
• W2149291473 title "Nuclear Export of MicroRNA Precursors" @default.
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• W2149291473 doi "https://doi.org/10.1126/science.1090599" @default.
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