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• W2149291946 abstract "Infection of mice with the intracellular bacterium Listeria monocytogenes results in a strong CD8(+) T cell response that is critical for efficient control of infection. We used CD28-deficient mice to characterize the function of CD28 during Listeria infection, with a main emphasis on Listeria-specific CD8(+) T cells. Frequencies and effector functions of these T cells were determined using MHC class I tetramers, single cell IFN-gamma production and Listeria-specific cytotoxicity. During primary Listeria infection of CD28(-/-) mice we observed significantly reduced numbers of Listeria-specific CD8(+) T cells and only marginal levels of specific IFN-gamma production and cytotoxicity. Although frequencies were also reduced in CD28(-/-) mice during secondary response, we detected a considerable population of Listeria-specific CD8(+) T cells in these mice. In parallel, IFN-gamma production and cytotoxicity were observed, revealing that Listeria-specific CD8(+) T cells in CD28(-/-) mice expressed normal effector functions. Consistent with their impaired CD8(+) T cell activation, CD28(-/-) mice suffered from exacerbated listeriosis both after primary and secondary infection. These results demonstrate participation of CD28 signaling in the generation and expansion of Ag-specific CD8(+) T cells in listeriosis. However, Ag-specific CD8(+) T cells generated in the absence of CD28 differentiated into normal effector and memory T cells." @default.
• W2149291946 created "2016-06-24" @default.
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• W2149291946 date "2001-11-15" @default.
• W2149291946 modified "2023-09-24" @default.
• W2149291946 title "Role of CD28 for the Generation and Expansion of Antigen-Specific CD8+ T Lymphocytes During Infection with<i>Listeria monocytogenes</i>" @default.
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• W2149291946 doi "https://doi.org/10.4049/jimmunol.167.10.5620" @default.
• W2149291946 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11698433" @default.
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