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• W2149292210 endingPage "251" @default.
• W2149292210 startingPage "236" @default.
• W2149292210 abstract "Toxin–antitoxin (TA) gene cassettes are widely distributed across bacteria, archaea and bacteriophage. The chromosome of the α-proteobacterium, Caulobacter crescentus, encodes eight ParE/RelE-superfamily toxins that are organized into operons with their cognate antitoxins. A systematic genetic analysis of these parDE and relBE TA operons demonstrates that seven encode functional toxins. The one exception highlights an example of a non-functional toxin pseudogene. Chromosomally encoded ParD and RelB proteins function as antitoxins, inhibiting their adjacently encoded ParE and RelE toxins. However, these antitoxins do not functionally complement each other, even when overexpressed. Transcription of these paralogous TA systems is differentially regulated under distinct environmental conditions. These data support a model in which multiple TA paralogs encoded by a single bacterial chromosome form independent functional units with insulated protein–protein interactions. Further characterization of the parDE1 system at the single-cell level reveals that ParE1 toxin functions to inhibit cell division but not cell growth; residues at the C-terminus of ParE1 are critical for its stability and toxicity. While continuous ParE1 overexpression results in a substantial loss in cell viability at the population level, a fraction of cells escape toxicity, providing evidence that ParE1 toxicity is not uniform within clonal cell populations." @default.
• W2149292210 created "2016-06-24" @default.
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• W2149292210 date "2010-05-12" @default.
• W2149292210 modified "2023-10-18" @default.
• W2149292210 title "Interaction specificity, toxicity and regulation of a paralogous set of ParE/RelE-family toxin-antitoxin systems" @default.
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• W2149292210 doi "https://doi.org/10.1111/j.1365-2958.2010.07207.x" @default.
• W2149292210 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2907451" @default.
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• W2149292210 hasPublicationYear "2010" @default.
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