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- W2149292244 abstract "Grondel, J.L., Nouws, J.F.M., Schutte, A.R. & Driessens, F. Comparative pharmacokinetics of oxytetracycline in rainbow trout (Salmo gairdneri) and African catfish (Clarias gariepinus). J. vet. Pharmacol. Therap.12, 157–162. A comparative pharmacokinetic study was conducted in rainbow trout (Salmo gairdneri) and African catfish (Clarias gariepinus) following intravenous (i.v.) and intramuscular (i.m.) administration of oxytetracycline (OTC) at a dose rate of 60 mg/kg body weight. Trout and catfish were kept in aerated tap water in tanks at constant temperatures of 12°C and 25°C, respectively. The two- and three-compartment open models adequately described plasma drug disposition in African catfish and rainbow trout respectively, following i.v. OTC administration. Compared to catfish (Cop= 86 ± 10 μg/ml) an eightfold higher extrapolated zero time concentration was obtained in trout (Cop= 753 ± 290 μg/ ml). A significant difference was observed with respect to the relatively large apparent distribution volumes (Vd(area)) after i.v. OTC administration (trout, mean value: 2.1 l/kg; catfish, mean value: 1.3 l/kg). The mean final elimination half-lives of both fish species were greater than previously reported in mammals (trout, 89.5 h; catfish, 80.3 h). A mean maximum plasma concentration (Cmax = 56.9 μg/ml) was obtained in trout at 4 h after i.m. administration of OTC. In catfish a lower Cmax of 43.4 (μg/ml was determined at about 7 h. No significant difference was observed with respect to bioavailability following i.m. administration of OTC (trout, 85%; catfish, 86%)." @default.
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- W2149292244 date "1989-06-01" @default.
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- W2149292244 title "Comparative pharmacokinetics of oxytetracycline in rainbow trout (Salmo gairdneri) and African catfish (Clarias gariepinus)" @default.
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- W2149292244 doi "https://doi.org/10.1111/j.1365-2885.1989.tb00657.x" @default.
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