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• W2149293766 abstract "<i >Background</i>. Angiogenic factors following oncological surgery is important in tumor recurrence. Vascular endothelial growth factor (VEGF), angiopoietin 1 (Ang-1), Ang-2, soluble VEGF-receptor 1 (sVEGFR1) and sVEGFR2 may influence angiogenesis. This prospective study examined the influence of open and video-assisted thoracic surgery (VATS) lung resections for early stage non-small cell lung cancer (NSCLC) on postoperative circulating angiogenic factors. <i >Methods</i>. Forty-three consecutive patients underwent major lung resection through either VATS (<svg style=vertical-align:-0.17555pt;width:42.912498px; id=M1 height=10.9125 version=1.1 viewBox=0 0 42.912498 10.9125 width=42.912498 xmlns=http://www.w3.org/2000/svg> <g transform=matrix(1.25,0,0,-1.25,0,10.9125)> <g transform=translate(72,-63.27)> <text transform=matrix(1,0,0,-1,-71.95,63.5)> <tspan style=font-size: 12.50px; x=0 y=0>𝑛</tspan> <tspan style=font-size: 12.50px; x=9.6773224 y=0>=</tspan> <tspan style=font-size: 12.50px; x=21.71771 y=0>2</tspan> <tspan style=font-size: 12.50px; x=27.969212 y=0>3</tspan> </text> </g> </g> </svg>) or Open thoracotomy (<svg style=vertical-align:-0.17555pt;width:42.912498px; id=M2 height=10.9125 version=1.1 viewBox=0 0 42.912498 10.9125 width=42.912498 xmlns=http://www.w3.org/2000/svg> <g transform=matrix(1.25,0,0,-1.25,0,10.9125)> <g transform=translate(72,-63.27)> <text transform=matrix(1,0,0,-1,-71.95,63.5)> <tspan style=font-size: 12.50px; x=0 y=0>𝑛</tspan> <tspan style=font-size: 12.50px; x=9.6773224 y=0>=</tspan> <tspan style=font-size: 12.50px; x=21.71771 y=0>2</tspan> <tspan style=font-size: 12.50px; x=27.969212 y=0>0</tspan> </text> </g> </g> </svg>) over an 8-month period. Blood samples were collected preoperatively and postoperatively on days (POD) 1 and 3 for enzyme linked immunosorbent assay determination of angiogenic factors. <i >Results</i>. Patient demographics were comparable. For all patients undergoing major lung resection, postoperative Ang-1 and sVEGFR2 levels were significantly decreased, while Ang-2 and sVEGFR1 levels markedly increased. No significant peri-operative changes in VEGF levels were observed. Compared with open group, VATS had significantly lower plasma levels of VEGF (VATS <svg style=vertical-align:-1.09097pt;width:56.849998px; id=M3 height=12.05 version=1.1 viewBox=0 0 56.849998 12.05 width=56.849998 xmlns=http://www.w3.org/2000/svg> <g transform=matrix(1.25,0,0,-1.25,0,12.05)> <g transform=translate(72,-62.36)> <text transform=matrix(1,0,0,-1,-71.95,63.5)> <tspan style=font-size: 12.50px; x=0 y=0>1</tspan> <tspan style=font-size: 12.50px; x=6.2515001 y=0>7</tspan> <tspan style=font-size: 12.50px; x=12.503 y=0>0</tspan> <tspan style=font-size: 12.50px; x=21.530167 y=0>±</tspan> <tspan style=font-size: 12.50px; x=32.870388 y=0>9</tspan> <tspan style=font-size: 12.50px; x=39.121887 y=0>3</tspan> </text> </g> </g> </svg>&#x2009;pg/mL; Open <svg style=vertical-align:-1.09097pt;width:64.662498px; id=M4 height=12.175 version=1.1 viewBox=0 0 64.662498 12.175 width=64.662498 xmlns=http://www.w3.org/2000/svg> <g transform=matrix(1.25,0,0,-1.25,0,12.175)> <g transform=translate(72,-62.26)> <text transform=matrix(1,0,0,-1,-71.95,63.4)> <tspan style=font-size: 12.50px; x=0 y=0>4</tspan> <tspan style=font-size: 12.50px; x=6.2515001 y=0>8</tspan> <tspan style=font-size: 12.50px; x=12.503 y=0>6</tspan> <tspan style=font-size: 12.50px; x=21.530167 y=0>±</tspan> <tspan style=font-size: 12.50px; x=32.870388 y=0>6</tspan> <tspan style=font-size: 12.50px; x=39.121887 y=0>4</tspan> <tspan style=font-size: 12.50px; x=45.373386 y=0>1</tspan> </text> </g> </g> </svg>&#x2009;pg/mL; <svg style=vertical-align:-0.17555pt;width:56.150002px; id=M5 height=10.9125 version=1.1 viewBox=0 0 56.150002 10.9125 width=56.150002 xmlns=http://www.w3.org/2000/svg> <g transform=matrix(1.25,0,0,-1.25,0,10.9125)> <g transform=translate(72,-63.27)> <text transform=matrix(1,0,0,-1,-71.95,63.5)> <tspan style=font-size: 12.50px; x=0 y=0>𝑃</tspan> <tspan style=font-size: 12.50px; x=10.890113 y=0>=</tspan> <tspan style=font-size: 12.50px; x=22.930502 y=0>0</tspan> <tspan style=font-size: 12.50px; x=29.182001 y=0>.</tspan> <tspan style=font-size: 12.50px; x=32.307751 y=0>0</tspan> <tspan style=font-size: 12.50px; x=38.559254 y=0>4</tspan> </text> </g> </g> </svg>) and Ang-2 (VATS <svg style=vertical-align:-1.09097pt;width:80.287498px; id=M6 height=12.05 version=1.1 viewBox=0 0 80.287498 12.05 width=80.287498 xmlns=http://www.w3.org/2000/svg> <g transform=matrix(1.25,0,0,-1.25,0,12.05)> <g transform=translate(72,-62.36)> <text transform=matrix(1,0,0,-1,-71.95,63.5)> <tspan style=font-size: 12.50px; x=0 y=0>2</tspan> <tspan style=font-size: 12.50px; x=6.2515001 y=0>4</tspan> <tspan style=font-size: 12.50px; x=12.503 y=0>8</tspan> <tspan style=font-size: 12.50px; x=18.754499 y=0>4</tspan> <tspan style=font-size: 12.50px; x=27.781666 y=0>±</tspan> <tspan style=font-size: 12.50px; x=39.121887 y=0>1</tspan> <tspan style=font-size: 12.50px; x=45.373386 y=0>1</tspan> <tspan style=font-size: 12.50px; x=51.624886 y=0>1</tspan> <tspan style=font-size: 12.50px; x=57.876389 y=0>9</tspan> </text> </g> </g> </svg>&#x2009;pg/mL; Open <svg style=vertical-align:-1.09097pt;width:80.287498px; id=M7 height=12.05 version=1.1 viewBox=0 0 80.287498 12.05 width=80.287498 xmlns=http://www.w3.org/2000/svg> <g transform=matrix(1.25,0,0,-1.25,0,12.05)> <g transform=translate(72,-62.36)> <text transform=matrix(1,0,0,-1,-71.95,63.5)> <tspan style=font-size: 12.50px; x=0 y=0>3</tspan> <tspan style=font-size: 12.50px; x=6.2515001 y=0>3</tspan> <tspan style=font-size: 12.50px; x=12.503 y=0>7</tspan> <tspan style=font-size: 12.50px; x=18.754499 y=0>9</tspan> <tspan style=font-size: 12.50px; x=27.781666 y=0>±</tspan> <tspan style=font-size: 12.50px; x=39.121887 y=0>1</tspan> <tspan style=font-size: 12.50px; x=45.373386 y=0>2</tspan> <tspan style=font-size: 12.50px; x=51.624886 y=0>8</tspan> <tspan style=font-size: 12.50px; x=57.876389 y=0>7</tspan> </text> </g> </g> </svg>&#x2009;pg/mL; <svg style=vertical-align:-0.17555pt;width:63.962502px; id=M8 height=11.0375 version=1.1 viewBox=0 0 63.962502 11.0375 width=63.962502 xmlns=http://www.w3.org/2000/svg> <g transform=matrix(1.25,0,0,-1.25,0,11.0375)> <g transform=translate(72,-63.17)> <text transform=matrix(1,0,0,-1,-71.95,63.4)> <tspan style=font-size: 12.50px; x=0 y=0>𝑃</tspan> <tspan style=font-size: 12.50px; x=10.890113 y=0>=</tspan> <tspan style=font-size: 12.50px; x=22.930502 y=0>0</tspan> <tspan style=font-size: 12.50px; x=29.182001 y=0>.</tspan> <tspan style=font-size: 12.50px; x=32.307751 y=0>0</tspan> <tspan style=font-size: 12.50px; x=38.559254 y=0>2</tspan> <tspan style=font-size: 12.50px; x=44.810753 y=0>6</tspan> </text> </g> </g> </svg>) on POD3. <i >Conclusions</i>. Major lung resection for early stage NSCLC leads to a pro-angiogenic status, with increased Ang-2 and decreased Ang-1 productions. VATS is associated with an attenuated angiogenic response with lower circulating VEGF and Ang-2 levels compared with open. Such differences in angiogenic factors may be important in lung cancer biology and recurrence following surgery." @default.
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• W2149293766 date "2012-01-01" @default.
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• W2149293766 title "Angiogenic Response to Major Lung Resection for Non-Small Cell Lung Cancer with Video-Assisted Thoracic Surgical and Open Access" @default.
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