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• W2149293899 abstract "Spatial regulation of the secretory machinery is essential for the formation of a new bud in Saccharomyces cerevisiae. Yet, the mechanisms underlying cross-talk between the secretory and the cell-polarity-establishment machineries have not been fully elucidated. Here, we report that Sec15p, a subunit of the exocyst complex, might provide one line of communication. Not only is Sec15p an effector of the rab protein Sec4p, the master regulator of post-Golgi trafficking, but it also interacts with components of the polarity-establishment machinery. We have demonstrated a direct physical interaction between Sec15p and Bem1p, a protein involved in the Cdc42p-mediated polarity-establishment pathway, confirming a prior two-hybrid study. When this interaction is compromised, as in the case of cells lacking the N-terminal 138 residues of Bem1p, including the first Src-homology 3 (SH3) domain, the localization of green fluorescent protein (GFP)-tagged Sec15 is affected, especially in the early stage of bud growth. In addition, Sec15-1p, which is defective in Bem1p binding, mislocalizes along with Sec8p, another exocyst subunit. Overall, our evidence suggests that the interaction of Sec15p with Bem1p is important for Sec15p localization at the early stage of bud growth and, through this interaction, Sec15p might play a crucial role in integrating the signals between Sec4p and the components of the early-polarity-establishment machinery. This, in turn, helps to coordinate the secretory pathway and polarized bud growth." @default.
• W2149293899 created "2016-06-24" @default.
• W2149293899 creator A5015763775 @default.
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• W2149293899 date "2006-03-01" @default.
• W2149293899 modified "2023-09-23" @default.
• W2149293899 title "The polarity-establishment component Bem1p interacts with the exocyst complex through the Sec15p subunit" @default.
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• W2149293899 doi "https://doi.org/10.1242/jcs.02849" @default.
• W2149293899 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16478783" @default.
• W2149293899 hasPublicationYear "2006" @default.
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