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• W2149294505 startingPage "450" @default.
• W2149294505 abstract "The human leukemic cell line AML-193 was tested for its proliferative response to endogenously produced autocrine factors and to a variety of cytokines and colony-stimulating factors. Cells grown in the absence of GM-CSF incorporated tritiated thymidine, and this was partially reversed by adding neutralizing anti-GM-CSF antibodies to the culture medium, suggesting that it was due, at least in part, to autocrine GM-CSF production. This was confirmed by immunopurification of a GM-CSF-like activity from cell supernatant of AML-193 cells grown in serum free medium in the absence of exogenous GM-CSF. When AML-193 cells were cultured with GM-CSF in combination with other cytokines, lnterleukin-1 α and β (IL-I α and β), lnterleukin-3 (IL-3), lnterleukin-6 (IL-6), granulocyte colony-stimulating factor (G-CSF) and tumor necrosis factor a (TNFα), none of them affected the concentration of GM-CSF required to induce 50% of maximum proliferation (D50). However, the maximum proliferation induced by GM-CSF alone was drastically decreased by IL-I α, IL β and TNFα. Inhibition caused by exposure of the AML-193 to IL-I for up to 24 hr was reversible, ruling out a direct cytotoxic effect." @default.
• W2149294505 created "2016-06-24" @default.
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• W2149294505 date "1991-02-01" @default.
• W2149294505 modified "2023-09-27" @default.
• W2149294505 title "Growth regulation of the AML-193 leukemic cell line: Evidence for autocrine production of granulocyte-macrophage colony-stimulating factor (GM-CSF), and inhibition of GM-CSF-dependent cell proliferation by interleukin-1 (IL-1) and tumor necrosis factor (tnfα)" @default.
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• W2149294505 doi "https://doi.org/10.1002/ijc.2910470324" @default.
• W2149294505 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1993554" @default.
• W2149294505 hasPublicationYear "1991" @default.
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