FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149295557> ?p ?o ?g. }

• W2149295557 endingPage "992" @default.
• W2149295557 startingPage "977" @default.
• W2149295557 abstract "Cryptococcus neoformans metallothioneins (MTs), CnMT1 and CnMT2, have been identified as essential infectivity and virulence factors of this pathogen. Both MTs are unusually long Cu-thioneins, exhibiting protein architecture and metal-binding abilities compatible with the hypothesis of resulting from three and five tandem repetitions of 7-Cys motives, respectively, each of them folding into Cu5-clusters. Through the study of the Zn(II)- and Cu(I)-binding capabilities of several CnMT1 truncated mutants, we show that a 7-Cys segment of CnMT1 folds into Cu5-species, of additive capacity when joined in tandem. All the obtained Cu-complexes share practically similar architectural features, if judging by their almost equivalent CD fingerprints, and they also share their capacity to restore copper tolerance in MT-devoid yeast cells. Besides the analysis of the modular composition of these long fungal MTs, we evaluate the features of the Cys-rich stretch spacer and flanking sequences that allow the construction of stable metal clusters by adjacent union of binding modules. Overall, our data support a mechanism by which some microbial MTs may have evolved to enlarge their original metal co-ordination capacity under the specific selective pressure of counteracting the Cu-based immunity mechanisms evolved by the infected hosts." @default.
• W2149295557 created "2016-06-24" @default.
• W2149295557 creator A5010145724 @default.
• W2149295557 creator A5016293691 @default.
• W2149295557 creator A5021623575 @default.
• W2149295557 creator A5043533923 @default.
• W2149295557 creator A5078161933 @default.
• W2149295557 date "2015-09-15" @default.
• W2149295557 modified "2023-10-16" @default.
• W2149295557 title "Understanding the 7-Cys module amplification ofC. neoformansmetallothioneins: how high capacity Cu-binding polypeptides are built to neutralize host nutritional immunity" @default.
• W2149295557 cites W1483456869 @default.
• W2149295557 cites W1521003697 @default.
• W2149295557 cites W1556774084 @default.
• W2149295557 cites W1902964315 @default.
• W2149295557 cites W1964348652 @default.
• W2149295557 cites W1964910363 @default.
• W2149295557 cites W1980423250 @default.
• W2149295557 cites W1983882206 @default.
• W2149295557 cites W1988261052 @default.
• W2149295557 cites W2000299318 @default.
• W2149295557 cites W2001427959 @default.
• W2149295557 cites W2003072572 @default.
• W2149295557 cites W2007493406 @default.
• W2149295557 cites W2030581562 @default.
• W2149295557 cites W2032044345 @default.
• W2149295557 cites W2038844755 @default.
• W2149295557 cites W2048443522 @default.
• W2149295557 cites W2053964529 @default.
• W2149295557 cites W2060062898 @default.
• W2149295557 cites W2066119305 @default.
• W2149295557 cites W2071927309 @default.
• W2149295557 cites W2079114976 @default.
• W2149295557 cites W2079492124 @default.
• W2149295557 cites W2083278094 @default.
• W2149295557 cites W2083704039 @default.
• W2149295557 cites W2088741681 @default.
• W2149295557 cites W2097666362 @default.
• W2149295557 cites W2104863787 @default.
• W2149295557 cites W2110279436 @default.
• W2149295557 cites W2117999711 @default.
• W2149295557 cites W2119046804 @default.
• W2149295557 cites W2126740905 @default.
• W2149295557 cites W2132629607 @default.
• W2149295557 cites W2140215126 @default.
• W2149295557 cites W2142963542 @default.
• W2149295557 cites W2149176191 @default.
• W2149295557 cites W2157801059 @default.
• W2149295557 cites W2167087440 @default.
• W2149295557 cites W2168389268 @default.
• W2149295557 cites W2315406550 @default.
• W2149295557 cites W2338841923 @default.
• W2149295557 doi "https://doi.org/10.1111/mmi.13171" @default.
• W2149295557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26287377" @default.
• W2149295557 hasPublicationYear "2015" @default.
• W2149295557 type Work @default.
• W2149295557 sameAs 2149295557 @default.
• W2149295557 citedByCount "4" @default.
• W2149295557 countsByYear W21492955572015 @default.
• W2149295557 countsByYear W21492955572016 @default.
• W2149295557 countsByYear W21492955572018 @default.
• W2149295557 countsByYear W21492955572019 @default.
• W2149295557 crossrefType "journal-article" @default.
• W2149295557 hasAuthorship W2149295557A5010145724 @default.
• W2149295557 hasAuthorship W2149295557A5016293691 @default.
• W2149295557 hasAuthorship W2149295557A5021623575 @default.
• W2149295557 hasAuthorship W2149295557A5043533923 @default.
• W2149295557 hasAuthorship W2149295557A5078161933 @default.
• W2149295557 hasBestOaLocation W21492955571 @default.
• W2149295557 hasConcept C104292427 @default.
• W2149295557 hasConcept C104317684 @default.
• W2149295557 hasConcept C126831891 @default.
• W2149295557 hasConcept C141231307 @default.
• W2149295557 hasConcept C159985019 @default.
• W2149295557 hasConcept C192562407 @default.
• W2149295557 hasConcept C27149982 @default.
• W2149295557 hasConcept C2777814067 @default.
• W2149295557 hasConcept C2777893358 @default.
• W2149295557 hasConcept C2779341262 @default.
• W2149295557 hasConcept C51785407 @default.
• W2149295557 hasConcept C54355233 @default.
• W2149295557 hasConcept C55493867 @default.
• W2149295557 hasConcept C60987743 @default.
• W2149295557 hasConcept C70721500 @default.
• W2149295557 hasConcept C86803240 @default.
• W2149295557 hasConcept C8891405 @default.
• W2149295557 hasConceptScore W2149295557C104292427 @default.
• W2149295557 hasConceptScore W2149295557C104317684 @default.
• W2149295557 hasConceptScore W2149295557C126831891 @default.
• W2149295557 hasConceptScore W2149295557C141231307 @default.
• W2149295557 hasConceptScore W2149295557C159985019 @default.
• W2149295557 hasConceptScore W2149295557C192562407 @default.
• W2149295557 hasConceptScore W2149295557C27149982 @default.
• W2149295557 hasConceptScore W2149295557C2777814067 @default.
• W2149295557 hasConceptScore W2149295557C2777893358 @default.
• W2149295557 hasConceptScore W2149295557C2779341262 @default.
• W2149295557 hasConceptScore W2149295557C51785407 @default.
• W2149295557 hasConceptScore W2149295557C54355233 @default.
• W2149295557 hasConceptScore W2149295557C55493867 @default.

• next