FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149295638> ?p ?o ?g. }

• W2149295638 endingPage "R903" @default.
• W2149295638 startingPage "R894" @default.
• W2149295638 abstract "Recent epidemiological, clinical, and experimental studies have demonstrated important links between sleep duration and architecture, circadian rhythms, and metabolism, although the genetic pathways that interconnect these processes are not well understood. Leptin is a circulating hormone and major adiposity signal involved in long-term energy homeostasis. In this study, we tested the hypothesis that leptin deficiency leads to impairments in sleep-wake regulation. Male ob/ob mice, a genetic model of leptin deficiency, had significantly disrupted sleep architecture with an elevated number of arousals from sleep [wild-type (WT) mice, 108.2 +/- 7.2 vs. ob/ob mice, 148.4 +/- 4.5, P < 0.001] and increased stage shifts (WT, 519.1 +/- 25.2 vs. ob/ob, 748.0 +/- 38.8, P < 0.001) compared with WT mice. Ob/ob mice also had more frequent, but shorter-lasting sleep bouts compared with WT mice, indicating impaired sleep consolidation. Interestingly, ob/ob mice showed changes in sleep time, with increased amounts of 24-h non-rapid eye movement (NREM) sleep (WT, 601.5 +/- 10.8 vs. ob/ob, 669.2 +/- 13.4 min, P < 0.001). Ob/ob mice had overall lower body temperature (WT, 35.1 +/- 0.2 vs. ob/ob, 33.4 +/- 0.2 degrees C, P < 0.001) and locomotor activity counts (WT, 25125 +/- 2137 vs. ob/ob, 5219 +/- 1759, P < 0.001). Ob/ob mice displayed an attenuated diurnal rhythm of sleep-wake stages, NREM delta power, and locomotor activity. Following sleep deprivation, ob/ob mice had smaller amounts of NREM and REM recovery sleep, both in terms of the magnitude and the duration of the recovery response. In combination, these results indicate that leptin deficiency disrupts the regulation of sleep architecture and diurnal rhythmicity." @default.
• W2149295638 created "2016-06-24" @default.
• W2149295638 creator A5004881384 @default.
• W2149295638 creator A5009049698 @default.
• W2149295638 creator A5023940237 @default.
• W2149295638 creator A5055162386 @default.
• W2149295638 creator A5084820716 @default.
• W2149295638 creator A5089869221 @default.
• W2149295638 date "2006-04-01" @default.
• W2149295638 modified "2023-09-27" @default.
• W2149295638 title "Altered sleep regulation in leptin-deficient mice" @default.
• W2149295638 cites W1486463812 @default.
• W2149295638 cites W150965689 @default.
• W2149295638 cites W1640809349 @default.
• W2149295638 cites W1896220440 @default.
• W2149295638 cites W1963609767 @default.
• W2149295638 cites W1967667779 @default.
• W2149295638 cites W1969730990 @default.
• W2149295638 cites W1972191708 @default.
• W2149295638 cites W1974570654 @default.
• W2149295638 cites W1976095017 @default.
• W2149295638 cites W1977320288 @default.
• W2149295638 cites W1983643694 @default.
• W2149295638 cites W1985790075 @default.
• W2149295638 cites W1991836846 @default.
• W2149295638 cites W1996713062 @default.
• W2149295638 cites W2001516075 @default.
• W2149295638 cites W2007161557 @default.
• W2149295638 cites W2012210137 @default.
• W2149295638 cites W2020287085 @default.
• W2149295638 cites W2022367677 @default.
• W2149295638 cites W2025605322 @default.
• W2149295638 cites W2029718832 @default.
• W2149295638 cites W2041558739 @default.
• W2149295638 cites W2045058491 @default.
• W2149295638 cites W2051051060 @default.
• W2149295638 cites W2056759283 @default.
• W2149295638 cites W2060251751 @default.
• W2149295638 cites W2084451542 @default.
• W2149295638 cites W2086315306 @default.
• W2149295638 cites W2088954672 @default.
• W2149295638 cites W2095583390 @default.
• W2149295638 cites W2101280449 @default.
• W2149295638 cites W2105727933 @default.
• W2149295638 cites W2113087631 @default.
• W2149295638 cites W2113888930 @default.
• W2149295638 cites W2115070641 @default.
• W2149295638 cites W2115505164 @default.
• W2149295638 cites W2115505876 @default.
• W2149295638 cites W2116753388 @default.
• W2149295638 cites W2124292257 @default.
• W2149295638 cites W2125667577 @default.
• W2149295638 cites W2130357926 @default.
• W2149295638 cites W2136864883 @default.
• W2149295638 cites W2139826323 @default.
• W2149295638 cites W2147712103 @default.
• W2149295638 cites W2150132984 @default.
• W2149295638 cites W2156899873 @default.
• W2149295638 cites W2171589452 @default.
• W2149295638 cites W2182090213 @default.
• W2149295638 cites W2183236844 @default.
• W2149295638 cites W2186698777 @default.
• W2149295638 cites W2212045230 @default.
• W2149295638 cites W2441644216 @default.
• W2149295638 doi "https://doi.org/10.1152/ajpregu.00304.2005" @default.
• W2149295638 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16293682" @default.
• W2149295638 hasPublicationYear "2006" @default.
• W2149295638 type Work @default.
• W2149295638 sameAs 2149295638 @default.
• W2149295638 citedByCount "166" @default.
• W2149295638 countsByYear W21492956382012 @default.
• W2149295638 countsByYear W21492956382013 @default.
• W2149295638 countsByYear W21492956382014 @default.
• W2149295638 countsByYear W21492956382015 @default.
• W2149295638 countsByYear W21492956382016 @default.
• W2149295638 countsByYear W21492956382017 @default.
• W2149295638 countsByYear W21492956382018 @default.
• W2149295638 countsByYear W21492956382019 @default.
• W2149295638 countsByYear W21492956382020 @default.
• W2149295638 countsByYear W21492956382021 @default.
• W2149295638 countsByYear W21492956382022 @default.
• W2149295638 countsByYear W21492956382023 @default.
• W2149295638 crossrefType "journal-article" @default.
• W2149295638 hasAuthorship W2149295638A5004881384 @default.
• W2149295638 hasAuthorship W2149295638A5009049698 @default.
• W2149295638 hasAuthorship W2149295638A5023940237 @default.
• W2149295638 hasAuthorship W2149295638A5055162386 @default.
• W2149295638 hasAuthorship W2149295638A5084820716 @default.
• W2149295638 hasAuthorship W2149295638A5089869221 @default.
• W2149295638 hasConcept C111919701 @default.
• W2149295638 hasConcept C121446783 @default.
• W2149295638 hasConcept C126322002 @default.
• W2149295638 hasConcept C134018914 @default.
• W2149295638 hasConcept C153050134 @default.
• W2149295638 hasConcept C169760540 @default.
• W2149295638 hasConcept C20566671 @default.
• W2149295638 hasConcept C2775841894 @default.
• W2149295638 hasConcept C2778329153 @default.

• next