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• W2149295658 abstract "Natural killer (NK) cells are a key component of innate immunity involved not only in the elimination of virus-infected or tumor cells but also in the regulation of the immune response by producing cytokines and chemokines that can activate other cellular components of innate and adaptive immunity. NK cell subsets are differentially affected by aging. Whereas CD56^bright cells are decreased in healthy elderly individuals, the CD56^dim subset is expanded. The expression of CD57, a marker of highly differentiated NK cells, is increased in the elderly; this supports the notion that a remodeling process of NK cell subsets occurs in aging with a gradual decrease in more immature CD56^bright NK cells and an increase in highly differentiated CD56^dim CD57+ NK cells. This NK cell redistribution can explain many of the phenotypic and functional changes in NK cells associated with healthy aging such as decreased proliferation and the maintenance of CD16-dependent cytotoxicity." @default.
• W2149295658 created "2016-06-24" @default.
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• W2149295658 date "2011-01-01" @default.
• W2149295658 modified "2023-10-07" @default.
• W2149295658 title "Immunosenescence of Human Natural Killer Cells" @default.
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• W2149295658 doi "https://doi.org/10.1159/000328005" @default.
• W2149295658 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21576928" @default.
• W2149295658 hasPublicationYear "2011" @default.
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