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• W2149296925 startingPage "L53" @default.
• W2149296925 abstract "The β 2 -adrenergic receptor (β 2 -AR) negatively regulates T cell activity through the activation of the G s /adenylyl cyclase/cAMP pathway. β 2 -AR desensitization, which can be induced by its phosphorylation, may have important consequences for the regulation of T cell function in asthma. In the present study we demonstrate that the C-C chemokine thymus and activation-regulated chemokine (TARC) impairs the ability of β 2 -agonist fenoterol to activate the cAMP downstream effector cAMP-responsive element binding protein (CREB) in freshly isolated human T cells. The TARC-induced activation of Src kinases resulted in membrane translocation of both G protein-coupled receptor kinase (GRK) 2 and β-arrestin. Moreover, TARC was able to induce Src-dependent serine phosphorylation of the β 2 -AR as well as its association with GRK2 and β-arrestin. Finally, in contrast to CREB, phosphorylation of Src and extracellular signal-regulated kinase was enhanced by fenoterol upon TARC pretreatment. In summary, we show for the first time that TARC exposure impairs β 2 -AR function in T cells. Our data suggest that this is mediated by Src-dependent activation of GRK2, resulting in receptor phosphorylation, binding to β-arrestin, and a switch from cAMP-dependent signaling to activation of the MAPK pathway. We propose that aberrant T cell control in the presence of endogenous β-agonists promotes T cell-mediated inflammation in asthma." @default.
• W2149296925 created "2016-06-24" @default.
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• W2149296925 date "2005-07-01" @default.
• W2149296925 modified "2023-09-24" @default.
• W2149296925 title "Exposure to TARC alters β₂-adrenergic receptor signaling in human peripheral blood T lymphocytes" @default.
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• W2149296925 doi "https://doi.org/10.1152/ajplung.00357.2004" @default.
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