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- W2149303608 abstract "As the drug discovery process evolves and demands more challenging and relevant assays, we have experienced a recent and significant escalation in the number of cell-based high-throughput assays for both small molecule and target identification screens. This has resulted in an increased need for the reproducible production of high quality cells in large quantities. Historically, manual cell culture was the only option available for providing cells in sufficient numbers for small molecule ultra-high-throughput screens (uHTSs), representing a technology gap in our automated cell culture process. Recently, we have applied an automated solution in the form of a novel 10-layer tissue culture flask, the HYPERFlask (Corning, Lowell, MA). This technology, when introduced as an upgrade to the SelecT (an automated cell culture system manufactured by The Automation Partnership, Ltd., Royston, England), provides a new approach to automating production of the high number of cells required for uHTS and consequently a highly desirable alternative to manual cell culture. The HYPERFlask has a surface area of 1720 cm 2 and can yield up to 3 × 10 8 cells after 3 days in culture. This can be compared to a typical yield of 2 × 10 7 cells from a T175 flask (with a surface area of 175 cm 2 ), the current standard flask type for automated cell culture on the SelecT. Cells grown in both flask types are of comparable quality, as demonstrated by equivalent cell viability, yield per cm 2 , functional response, and pharmacology." @default.
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- W2149303608 date "2008-06-01" @default.
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- W2149303608 title "Automated Application of a Novel High Yield, High Performance Tissue Culture Flask" @default.
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- W2149303608 doi "https://doi.org/10.1016/j.jala.2007.12.010" @default.
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