FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149303684> ?p ?o ?g. }

• W2149303684 endingPage "1604" @default.
• W2149303684 startingPage "1597" @default.
• W2149303684 abstract "Atherosclerosis may be viewed as an inflammatory disease process that includes early oxidative modification of LDLs, leading to foam cell formation. This oxidation hypothesis has gained general acceptance in recent years, and evidence for the role of lipoxygenases in initiation of, or participation in, the oxidative process is accumulating. However, the relative contribution of macrophage-expressed lipoxygenases to atherogenesis in vivo remains unknown. Here, we provide in vivo evidence for the role of 12/15-lipoxygenase in atherogenesis and demonstrate diminished plasma IgG autoantibodies to oxidized LDL epitopes in 12/15-lipoxygenase knockout mice crossbred with atherosclerosis-prone apo E-deficient mice (apo E-/-/L-12LO-/-). In chow-fed 15-week-old apo E-/-/L-12LO-/- mice, the extent of lesions in whole-aorta en face preparations (198 +/- 60 microm2) was strongly reduced (P < 0.001, n = 12) when compared with 12/15-lipoxygenase-expressing controls (apo E-/-/L-12LO+/+), which showed areas of lipid deposition (15,700 +/- 2,688 microm2) in the lesser curvature of the aortic arch, branch points, and in the abdominal aorta. These results were observed despite cholesterol, triglyceride, and lipoprotein levels that were similar to those in apo E-deficient mice. Evidence for reduced lesion development was observed even at 1 year of age in apo E-/-/L-12LO-/- mice. The combined data indicate a role for 12/15-lipoxygenase in the pathogenesis of atherosclerosis and suggest that inhibition of this enzyme may decrease disease progression." @default.
• W2149303684 created "2016-06-24" @default.
• W2149303684 creator A5032705392 @default.
• W2149303684 creator A5037079092 @default.
• W2149303684 creator A5062103520 @default.
• W2149303684 creator A5067149045 @default.
• W2149303684 creator A5067797353 @default.
• W2149303684 creator A5084143272 @default.
• W2149303684 creator A5089000198 @default.
• W2149303684 date "1999-06-01" @default.
• W2149303684 modified "2023-10-16" @default.
• W2149303684 title "Disruption of the 12/15-lipoxygenase gene diminishes atherosclerosis in apo E–deficient mice" @default.
• W2149303684 cites W1521799099 @default.
• W2149303684 cites W1540646729 @default.
• W2149303684 cites W1857052429 @default.
• W2149303684 cites W1964814612 @default.
• W2149303684 cites W1967459697 @default.
• W2149303684 cites W1968679020 @default.
• W2149303684 cites W1976621212 @default.
• W2149303684 cites W1978383066 @default.
• W2149303684 cites W1978704058 @default.
• W2149303684 cites W1981239721 @default.
• W2149303684 cites W1982703815 @default.
• W2149303684 cites W1984994852 @default.
• W2149303684 cites W1989123782 @default.
• W2149303684 cites W1993383276 @default.
• W2149303684 cites W2001399393 @default.
• W2149303684 cites W2003296127 @default.
• W2149303684 cites W2004704496 @default.
• W2149303684 cites W2005230846 @default.
• W2149303684 cites W2006384611 @default.
• W2149303684 cites W2008057379 @default.
• W2149303684 cites W2017315967 @default.
• W2149303684 cites W2018794044 @default.
• W2149303684 cites W2020186766 @default.
• W2149303684 cites W2022168012 @default.
• W2149303684 cites W2022439153 @default.
• W2149303684 cites W2026304372 @default.
• W2149303684 cites W2028841673 @default.
• W2149303684 cites W2029314163 @default.
• W2149303684 cites W2030720809 @default.
• W2149303684 cites W2032763669 @default.
• W2149303684 cites W2032786707 @default.
• W2149303684 cites W2033539598 @default.
• W2149303684 cites W2035252462 @default.
• W2149303684 cites W2036852690 @default.
• W2149303684 cites W2040579726 @default.
• W2149303684 cites W2048890665 @default.
• W2149303684 cites W2054145472 @default.
• W2149303684 cites W2058954135 @default.
• W2149303684 cites W2068210705 @default.
• W2149303684 cites W2081304820 @default.
• W2149303684 cites W2082987476 @default.
• W2149303684 cites W2087647782 @default.
• W2149303684 cites W2089190393 @default.
• W2149303684 cites W2091246594 @default.
• W2149303684 cites W2093782393 @default.
• W2149303684 cites W2102647393 @default.
• W2149303684 cites W2104573407 @default.
• W2149303684 cites W2107938935 @default.
• W2149303684 cites W2121972309 @default.
• W2149303684 cites W2122020349 @default.
• W2149303684 cites W2124237530 @default.
• W2149303684 cites W2137511741 @default.
• W2149303684 cites W2153609395 @default.
• W2149303684 cites W2155115159 @default.
• W2149303684 cites W2157677688 @default.
• W2149303684 cites W2163485744 @default.
• W2149303684 cites W2163624012 @default.
• W2149303684 cites W2238453035 @default.
• W2149303684 cites W2326202471 @default.
• W2149303684 cites W2340406612 @default.
• W2149303684 cites W3139808032 @default.
• W2149303684 doi "https://doi.org/10.1172/jci5897" @default.
• W2149303684 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/408369" @default.
• W2149303684 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10359569" @default.
• W2149303684 hasPublicationYear "1999" @default.
• W2149303684 type Work @default.
• W2149303684 sameAs 2149303684 @default.
• W2149303684 citedByCount "499" @default.
• W2149303684 countsByYear W21493036842012 @default.
• W2149303684 countsByYear W21493036842013 @default.
• W2149303684 countsByYear W21493036842014 @default.
• W2149303684 countsByYear W21493036842015 @default.
• W2149303684 countsByYear W21493036842016 @default.
• W2149303684 countsByYear W21493036842017 @default.
• W2149303684 countsByYear W21493036842018 @default.
• W2149303684 countsByYear W21493036842019 @default.
• W2149303684 countsByYear W21493036842020 @default.
• W2149303684 countsByYear W21493036842021 @default.
• W2149303684 countsByYear W21493036842022 @default.
• W2149303684 countsByYear W21493036842023 @default.
• W2149303684 crossrefType "journal-article" @default.
• W2149303684 hasAuthorship W2149303684A5032705392 @default.
• W2149303684 hasAuthorship W2149303684A5037079092 @default.
• W2149303684 hasAuthorship W2149303684A5062103520 @default.
• W2149303684 hasAuthorship W2149303684A5067149045 @default.
• W2149303684 hasAuthorship W2149303684A5067797353 @default.

• next