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- W2149304420 abstract "Toxoplasmosis represents the most frequent complication affecting the CNS of AIDS patients.In Europe and South America the prevalence of toxoplasmosis is higher than in the United States (50-75% to 15%), so the risk for the AIDS-associated toxoplasmosis is higher in this area, including Romania.Most of the AIDS patients have immunoglobulin G antibodies anti-Toxoplasma in their serum, like in the general population, so most of the cases represent a reactivation of a latent infection.We present a series of 5 cases with patients, aged between 19-29 years old, who developed cerebral toxoplasmosis.Three of the patients are multi-experienced, and for two patients the cerebral toxoplasmosis was the defining AIDS infection.Three patients had a CD4 count under 100 cells/cmm at the moment of their diagnosis, with low adherence for cART and for the prophylaxis with trimethoprim-sulfamethoxazole.All patients but one had detectable HIV viral load.Two of the patients are positive for B hepatitis, one of them also for hepatitis D.The clinical manifestations were persistent headache, confusion, lethargy, hemiparesis.All patients presented high levels for immunoglobulin G anti-Toxoplasma at the moment of the clinical manifestations, one patient presented immunoglobulin M anti-Toxoplasma.The MRI examinations revealed characteristic multiple lesions.The treatment was performed using trimethoprim-sulfamethoxazole for 6 weeks.The evolution of the patients under the treatment was favorable for all the patients, with the remission of the symptoms and without neurological complications; they received trimethoprim-sulfamethoxazole prophylaxis until their CD4 >200/cmm, for another three monthsAlthough difficult to diagnose, cerebral toxoplasmosis is treatable and curable, despite of all the associated AIDS pathology." @default.
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- W2149304420 date "2014-05-01" @default.
- W2149304420 modified "2023-10-07" @default.
- W2149304420 title "An obstacle to overcome: cerebral toxoplasmosis in patients living with HIV" @default.
- W2149304420 doi "https://doi.org/10.1186/1471-2334-14-s4-p48" @default.
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