Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149304739> ?p ?o ?g. }
- W2149304739 endingPage "848" @default.
- W2149304739 startingPage "833" @default.
- W2149304739 abstract "Genetically unstable tetraploid cells can promote tumorigenesis. Recent estimates suggest that ∼37% of human tumors have undergone a genome-doubling event during their development. This potentially oncogenic effect of tetraploidy is countered by a p53-dependent barrier to proliferation. However, the cellular defects and corresponding signaling pathways that trigger growth suppression in tetraploid cells are not known. Here, we combine RNAi screening and in vitro evolution approaches to demonstrate that cytokinesis failure activates the Hippo tumor suppressor pathway in cultured cells, as well as in naturally occurring tetraploid cells in vivo. Induction of the Hippo pathway is triggered in part by extra centrosomes, which alter small G protein signaling and activate LATS2 kinase. LATS2 in turn stabilizes p53 and inhibits the transcriptional regulators YAP and TAZ. These findings define an important tumor suppression mechanism and uncover adaptive mechanisms potentially available to nascent tumor cells that bypass this inhibitory regulation." @default.
- W2149304739 created "2016-06-24" @default.
- W2149304739 creator A5005475432 @default.
- W2149304739 creator A5020700010 @default.
- W2149304739 creator A5023275493 @default.
- W2149304739 creator A5024739591 @default.
- W2149304739 creator A5038764459 @default.
- W2149304739 creator A5047298909 @default.
- W2149304739 creator A5050653958 @default.
- W2149304739 creator A5076079215 @default.
- W2149304739 creator A5080140103 @default.
- W2149304739 date "2014-08-01" @default.
- W2149304739 modified "2023-10-09" @default.
- W2149304739 title "Cytokinesis Failure Triggers Hippo Tumor Suppressor Pathway Activation" @default.
- W2149304739 cites W1548202728 @default.
- W2149304739 cites W1561407320 @default.
- W2149304739 cites W1963587413 @default.
- W2149304739 cites W1970442105 @default.
- W2149304739 cites W1971248187 @default.
- W2149304739 cites W1974124532 @default.
- W2149304739 cites W1986791248 @default.
- W2149304739 cites W1996435746 @default.
- W2149304739 cites W2005815786 @default.
- W2149304739 cites W2006778392 @default.
- W2149304739 cites W2010749771 @default.
- W2149304739 cites W2012077724 @default.
- W2149304739 cites W2016661249 @default.
- W2149304739 cites W2023471348 @default.
- W2149304739 cites W2036358056 @default.
- W2149304739 cites W2036747263 @default.
- W2149304739 cites W2045802318 @default.
- W2149304739 cites W2051200214 @default.
- W2149304739 cites W2061058076 @default.
- W2149304739 cites W2064887851 @default.
- W2149304739 cites W2085234652 @default.
- W2149304739 cites W2088593944 @default.
- W2149304739 cites W2093021491 @default.
- W2149304739 cites W2095601153 @default.
- W2149304739 cites W2099268087 @default.
- W2149304739 cites W2101538557 @default.
- W2149304739 cites W2107012923 @default.
- W2149304739 cites W2107190139 @default.
- W2149304739 cites W2109838283 @default.
- W2149304739 cites W2112668385 @default.
- W2149304739 cites W2112933956 @default.
- W2149304739 cites W2118671972 @default.
- W2149304739 cites W2120795306 @default.
- W2149304739 cites W2121212012 @default.
- W2149304739 cites W2124957911 @default.
- W2149304739 cites W2133224984 @default.
- W2149304739 cites W2134590240 @default.
- W2149304739 cites W2135165925 @default.
- W2149304739 cites W2137220794 @default.
- W2149304739 cites W2141595533 @default.
- W2149304739 cites W2142583529 @default.
- W2149304739 cites W2144023435 @default.
- W2149304739 cites W2146337514 @default.
- W2149304739 cites W2148572322 @default.
- W2149304739 cites W2159376228 @default.
- W2149304739 cites W2163559297 @default.
- W2149304739 cites W2170490448 @default.
- W2149304739 cites W2171501785 @default.
- W2149304739 cites W2299816417 @default.
- W2149304739 doi "https://doi.org/10.1016/j.cell.2014.06.029" @default.
- W2149304739 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4136486" @default.
- W2149304739 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25126788" @default.
- W2149304739 hasPublicationYear "2014" @default.
- W2149304739 type Work @default.
- W2149304739 sameAs 2149304739 @default.
- W2149304739 citedByCount "304" @default.
- W2149304739 countsByYear W21493047392014 @default.
- W2149304739 countsByYear W21493047392015 @default.
- W2149304739 countsByYear W21493047392016 @default.
- W2149304739 countsByYear W21493047392017 @default.
- W2149304739 countsByYear W21493047392018 @default.
- W2149304739 countsByYear W21493047392019 @default.
- W2149304739 countsByYear W21493047392020 @default.
- W2149304739 countsByYear W21493047392021 @default.
- W2149304739 countsByYear W21493047392022 @default.
- W2149304739 countsByYear W21493047392023 @default.
- W2149304739 crossrefType "journal-article" @default.
- W2149304739 hasAuthorship W2149304739A5005475432 @default.
- W2149304739 hasAuthorship W2149304739A5020700010 @default.
- W2149304739 hasAuthorship W2149304739A5023275493 @default.
- W2149304739 hasAuthorship W2149304739A5024739591 @default.
- W2149304739 hasAuthorship W2149304739A5038764459 @default.
- W2149304739 hasAuthorship W2149304739A5047298909 @default.
- W2149304739 hasAuthorship W2149304739A5050653958 @default.
- W2149304739 hasAuthorship W2149304739A5076079215 @default.
- W2149304739 hasAuthorship W2149304739A5080140103 @default.
- W2149304739 hasBestOaLocation W21493047391 @default.
- W2149304739 hasConcept C104317684 @default.
- W2149304739 hasConcept C10447061 @default.
- W2149304739 hasConcept C1491633281 @default.
- W2149304739 hasConcept C172512520 @default.
- W2149304739 hasConcept C179185449 @default.
- W2149304739 hasConcept C29537977 @default.
- W2149304739 hasConcept C45472230 @default.