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• W2149306058 abstract "Successfully systemic gene therapy has been hindered by vector-related limitations, including toxicity and inefficient gene delivery to tumor cells after intravenous administration. In this study, we evaluated the potential of spherical polyethylenimine nanogels (M-PEIs) as a novel vector for intravenous delivery of plasmids to tumor cells. M-PEIs provided a sustained release of plasmids up to 14 days and were also effective in protecting plasmids from enzymatic degradation in serum-conditioned media. M-PEIs showed no obvious cytotoxicity to mammalian cells in vitro as well as to liver, heart and kidney in mice after intravenous injection. Importantly, following intravenous administration of M-PEIs/plasmid complexes into human hepatocellular carcinoma xenograft-bearing mice, green fluorescence protein reporter gene expression was predominantly found in the tumor. This study indicates that M-PEIs may be a candidate for systemic delivery of plasmids into tumors." @default.
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• W2149306058 date "2009-01-30" @default.
• W2149306058 modified "2023-10-17" @default.
• W2149306058 title "M-PEIs nanogels: potential nonviral vector for systemic plasmid delivery to tumor cells" @default.
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• W2149306058 doi "https://doi.org/10.1038/cgt.2009.11" @default.
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