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• W2149306765 abstract "Protein kinase C (PKC) has been shown to exert broad actions in modulating Ca2+ in cardiac myocytes, however, the effect of PKC in skeletal muscle cells is largely unknown. In this study, we examined the effect of the PKC inhibitor calphostin C (CC) and the PKC agonist phorbol 12-myristate 13-acetate (PMA) on intracellular Ca2+ handling in C2C12 skeletal myotubes and skinned skeletal muscle fibers of the rat. CC (250 nM) significantly prolonged (P = 0.01, n = 6), and the PKC agonist PMA (500 nM; P = 0.03, n = 6) significantly shortened the decay phase of electrically induced Ca2+ transients in C2C12 myotubes without affecting the amplitude or the time to peak of the transients. Skinned fiber studies showed that CC significantly inhibits SR Ca2+ uptake in skeletal muscle cells. PMA had no effect. CC also increased the peak of ATP-induced Ca2+ transients release by 94.2% (P < 0.0001) in the presence of extracellular Ca2+ and 54.5% (P = 0.04) without external Ca2+ via IP3-Ca2+ release pathway in C2C12 myotubes, while PMA had no effect, suggesting that CC may modulate IP3-induced Ca2+ release via a PKC-independent mechanism. CC at a concentration of 1 μM was able to induce a large sustained elevation in basal [Ca2+]i that was blocked by Ca2+ store depletion and the IP3 receptor blocker 2-APB. These results indicate that PKC plays a role in modulation of SR function in skeletal muscle cells, and the PKC inhibitor CC may alter Ca2+ handling via both PKC-dependent and PKC-independent pathways." @default.
• W2149306765 created "2016-06-24" @default.
• W2149306765 creator A5050059959 @default.
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• W2149306765 date "2006-05-01" @default.
• W2149306765 modified "2023-09-23" @default.
• W2149306765 title "The effect of the PKC inhibitor calphostin C and the PKC agonist phorbol 12-myristate 13-acetate on regulation of cytosolic Ca2+ in mammalian skeletal muscle cells" @default.
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• W2149306765 doi "https://doi.org/10.1016/j.taap.2005.07.023" @default.
• W2149306765 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16150473" @default.
• W2149306765 hasPublicationYear "2006" @default.
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