Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149307520> ?p ?o ?g. }
- W2149307520 endingPage "2248" @default.
- W2149307520 startingPage "2241" @default.
- W2149307520 abstract "Abstract Objectives Biocides are widely used to prevent infection. We aimed to determine whether exposure of Salmonella to various biocides could act as a driver of antibiotic resistance. Methods Salmonella enterica serovar Typhimurium was exposed to four biocides with differing modes of action. Antibiotic-resistant mutants were selected during exposure to all biocides and characterized phenotypically and genotypically to identify mechanisms of resistance. Results All biocides tested selected MDR mutants with decreased antibiotic susceptibility; these occurred randomly throughout the experiments. Mutations that resulted in de-repression of the multidrug efflux pump AcrAB-TolC were seen in MDR mutants. A novel mutation in rpoA was also selected and contributed to the MDR phenotype. Other mutants were highly resistant to both quinolone antibiotics and the biocide triclosan. Conclusions This study shows that exposure of bacteria to biocides can select for antibiotic-resistant mutants and this is mediated by clinically relevant mechanisms of resistance prevalent in human pathogens." @default.
- W2149307520 created "2016-06-24" @default.
- W2149307520 creator A5017196239 @default.
- W2149307520 creator A5019987484 @default.
- W2149307520 creator A5039363708 @default.
- W2149307520 creator A5067158234 @default.
- W2149307520 creator A5067887088 @default.
- W2149307520 creator A5077104162 @default.
- W2149307520 date "2015-05-07" @default.
- W2149307520 modified "2023-10-16" @default.
- W2149307520 title "Parallel evolutionary pathways to antibiotic resistance selected by biocide exposure" @default.
- W2149307520 cites W1969307309 @default.
- W2149307520 cites W1974665820 @default.
- W2149307520 cites W1989512904 @default.
- W2149307520 cites W2000707800 @default.
- W2149307520 cites W2002967849 @default.
- W2149307520 cites W2010264974 @default.
- W2149307520 cites W2014192657 @default.
- W2149307520 cites W2019153470 @default.
- W2149307520 cites W2020214312 @default.
- W2149307520 cites W2043887558 @default.
- W2149307520 cites W2062151275 @default.
- W2149307520 cites W2069224592 @default.
- W2149307520 cites W2078919927 @default.
- W2149307520 cites W2082592039 @default.
- W2149307520 cites W2083513354 @default.
- W2149307520 cites W2097516272 @default.
- W2149307520 cites W2098164808 @default.
- W2149307520 cites W2104239157 @default.
- W2149307520 cites W2109363737 @default.
- W2149307520 cites W2112327380 @default.
- W2149307520 cites W2115245313 @default.
- W2149307520 cites W2116515820 @default.
- W2149307520 cites W2125621081 @default.
- W2149307520 cites W2126824283 @default.
- W2149307520 cites W2132963724 @default.
- W2149307520 cites W2138213445 @default.
- W2149307520 cites W2141637785 @default.
- W2149307520 cites W2158728493 @default.
- W2149307520 cites W2159206412 @default.
- W2149307520 cites W2160654325 @default.
- W2149307520 cites W2163971377 @default.
- W2149307520 cites W2163984224 @default.
- W2149307520 cites W2165991316 @default.
- W2149307520 cites W2167305885 @default.
- W2149307520 cites W4241841228 @default.
- W2149307520 cites W4248560660 @default.
- W2149307520 doi "https://doi.org/10.1093/jac/dkv109" @default.
- W2149307520 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4500774" @default.
- W2149307520 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25953808" @default.
- W2149307520 hasPublicationYear "2015" @default.
- W2149307520 type Work @default.
- W2149307520 sameAs 2149307520 @default.
- W2149307520 citedByCount "110" @default.
- W2149307520 countsByYear W21493075202015 @default.
- W2149307520 countsByYear W21493075202016 @default.
- W2149307520 countsByYear W21493075202017 @default.
- W2149307520 countsByYear W21493075202018 @default.
- W2149307520 countsByYear W21493075202019 @default.
- W2149307520 countsByYear W21493075202020 @default.
- W2149307520 countsByYear W21493075202021 @default.
- W2149307520 countsByYear W21493075202022 @default.
- W2149307520 countsByYear W21493075202023 @default.
- W2149307520 crossrefType "journal-article" @default.
- W2149307520 hasAuthorship W2149307520A5017196239 @default.
- W2149307520 hasAuthorship W2149307520A5019987484 @default.
- W2149307520 hasAuthorship W2149307520A5039363708 @default.
- W2149307520 hasAuthorship W2149307520A5067158234 @default.
- W2149307520 hasAuthorship W2149307520A5067887088 @default.
- W2149307520 hasAuthorship W2149307520A5077104162 @default.
- W2149307520 hasBestOaLocation W21493075201 @default.
- W2149307520 hasConcept C104317684 @default.
- W2149307520 hasConcept C114851261 @default.
- W2149307520 hasConcept C133936738 @default.
- W2149307520 hasConcept C142724271 @default.
- W2149307520 hasConcept C143065580 @default.
- W2149307520 hasConcept C197471484 @default.
- W2149307520 hasConcept C200082930 @default.
- W2149307520 hasConcept C2779607309 @default.
- W2149307520 hasConcept C2781065037 @default.
- W2149307520 hasConcept C2781289450 @default.
- W2149307520 hasConcept C501593827 @default.
- W2149307520 hasConcept C523546767 @default.
- W2149307520 hasConcept C54355233 @default.
- W2149307520 hasConcept C71924100 @default.
- W2149307520 hasConcept C86803240 @default.
- W2149307520 hasConcept C89423630 @default.
- W2149307520 hasConcept C94665300 @default.
- W2149307520 hasConceptScore W2149307520C104317684 @default.
- W2149307520 hasConceptScore W2149307520C114851261 @default.
- W2149307520 hasConceptScore W2149307520C133936738 @default.
- W2149307520 hasConceptScore W2149307520C142724271 @default.
- W2149307520 hasConceptScore W2149307520C143065580 @default.
- W2149307520 hasConceptScore W2149307520C197471484 @default.
- W2149307520 hasConceptScore W2149307520C200082930 @default.
- W2149307520 hasConceptScore W2149307520C2779607309 @default.
- W2149307520 hasConceptScore W2149307520C2781065037 @default.
- W2149307520 hasConceptScore W2149307520C2781289450 @default.