Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149309062> ?p ?o ?g. }
- W2149309062 endingPage "G150" @default.
- W2149309062 startingPage "G143" @default.
- W2149309062 abstract "Peritoneal fibrosis formation is a consequence of inflammation/injury and a significant medical problem to be solved. The effects of soluble VEGF receptor type I (sFlt-1) gene transfer on experimental peritoneal fibrosis were examined and compared with soluble transforming growth factor-beta (TGF-beta) receptor type II (sTGF beta RII) gene transfer. Male C57BL/6 mice were injected with 1.5 x 10(8) plaque-forming unit of adenovirus encoding active TGF-beta (AdTGF beta) intraperitoneally. Some mice had been treated with sTGF betaRII or sFlt-1 plasmid injection into skeletal muscle with electroporation 4 days before virus administration. Mice were euthanized at day 14 after virus administration. AdTGF beta induced significant elevation of serum active TGF-beta, caused significant inflammatory response [weight loss, elevation of serum amyloid-P (SAP) and IL-12, increased expression of monocyte chemoattractant protein-1 (MCP-1) mRNA], and induced marked thickening of the peritoneum and collagen deposition. Gene transfer of sFlt-1 reduced the collagen deposition approximately 81% in mesenteric tissue. Treatment with sFlt-1 decreased ICAM-1 and MCP-1 mRNA expression significantly. Significant negative correlation between serum sFlt-1 and placental growth factor level was observed, whereas there was no significant negative correlation between sFlt-1 and VEGF. On the other hand, sTGF beta RII treatment enhanced the AdTGF beta-induced inflammation (significant elevation of SAP, TNF-alpha, and IL-12 levels and upregulation of ICAM-1 and MCP-1 mRNA expressions) and failed to prevent collagen deposition. These observations indicate that sFlt-1 gene transfer might be of therapeutic benefit in peritoneal fibrosis." @default.
- W2149309062 created "2016-06-24" @default.
- W2149309062 creator A5003542106 @default.
- W2149309062 creator A5005295653 @default.
- W2149309062 creator A5014977823 @default.
- W2149309062 creator A5016221625 @default.
- W2149309062 creator A5030287034 @default.
- W2149309062 creator A5033257813 @default.
- W2149309062 creator A5034545983 @default.
- W2149309062 creator A5056416355 @default.
- W2149309062 creator A5075158215 @default.
- W2149309062 date "2005-01-01" @default.
- W2149309062 modified "2023-10-13" @default.
- W2149309062 title "The gene transfer of soluble VEGF type I receptor (Flt-1) attenuates peritoneal fibrosis formation in mice but not soluble TGF-β type II receptor gene transfer" @default.
- W2149309062 cites W1494416455 @default.
- W2149309062 cites W1509507060 @default.
- W2149309062 cites W1541589221 @default.
- W2149309062 cites W1600542667 @default.
- W2149309062 cites W1606157168 @default.
- W2149309062 cites W1807482481 @default.
- W2149309062 cites W1875554126 @default.
- W2149309062 cites W1964820926 @default.
- W2149309062 cites W1975710755 @default.
- W2149309062 cites W1981806695 @default.
- W2149309062 cites W1983031935 @default.
- W2149309062 cites W1985321490 @default.
- W2149309062 cites W1993066239 @default.
- W2149309062 cites W2015996457 @default.
- W2149309062 cites W2017041417 @default.
- W2149309062 cites W2017627019 @default.
- W2149309062 cites W2024531819 @default.
- W2149309062 cites W2024888501 @default.
- W2149309062 cites W2026038921 @default.
- W2149309062 cites W2026196936 @default.
- W2149309062 cites W2029763523 @default.
- W2149309062 cites W2035404114 @default.
- W2149309062 cites W2035504341 @default.
- W2149309062 cites W2037749195 @default.
- W2149309062 cites W2043703101 @default.
- W2149309062 cites W2044069347 @default.
- W2149309062 cites W2050061160 @default.
- W2149309062 cites W2051268134 @default.
- W2149309062 cites W2056242981 @default.
- W2149309062 cites W2060928333 @default.
- W2149309062 cites W2062199188 @default.
- W2149309062 cites W2065354528 @default.
- W2149309062 cites W2075404842 @default.
- W2149309062 cites W2079517510 @default.
- W2149309062 cites W2088346043 @default.
- W2149309062 cites W2092934529 @default.
- W2149309062 cites W2105669313 @default.
- W2149309062 cites W2120045564 @default.
- W2149309062 cites W2120555366 @default.
- W2149309062 cites W2126270623 @default.
- W2149309062 cites W2151268204 @default.
- W2149309062 cites W2155739651 @default.
- W2149309062 cites W2158121838 @default.
- W2149309062 cites W2159600810 @default.
- W2149309062 cites W2160551571 @default.
- W2149309062 cites W2161479548 @default.
- W2149309062 cites W2163296212 @default.
- W2149309062 cites W2292615818 @default.
- W2149309062 cites W2293658187 @default.
- W2149309062 cites W2343527743 @default.
- W2149309062 cites W2399412480 @default.
- W2149309062 doi "https://doi.org/10.1152/ajpgi.00186.2004" @default.
- W2149309062 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15297261" @default.
- W2149309062 hasPublicationYear "2005" @default.
- W2149309062 type Work @default.
- W2149309062 sameAs 2149309062 @default.
- W2149309062 citedByCount "25" @default.
- W2149309062 countsByYear W21493090622012 @default.
- W2149309062 countsByYear W21493090622015 @default.
- W2149309062 countsByYear W21493090622016 @default.
- W2149309062 countsByYear W21493090622018 @default.
- W2149309062 countsByYear W21493090622020 @default.
- W2149309062 crossrefType "journal-article" @default.
- W2149309062 hasAuthorship W2149309062A5003542106 @default.
- W2149309062 hasAuthorship W2149309062A5005295653 @default.
- W2149309062 hasAuthorship W2149309062A5014977823 @default.
- W2149309062 hasAuthorship W2149309062A5016221625 @default.
- W2149309062 hasAuthorship W2149309062A5030287034 @default.
- W2149309062 hasAuthorship W2149309062A5033257813 @default.
- W2149309062 hasAuthorship W2149309062A5034545983 @default.
- W2149309062 hasAuthorship W2149309062A5056416355 @default.
- W2149309062 hasAuthorship W2149309062A5075158215 @default.
- W2149309062 hasConcept C104317684 @default.
- W2149309062 hasConcept C118131993 @default.
- W2149309062 hasConcept C126322002 @default.
- W2149309062 hasConcept C134018914 @default.
- W2149309062 hasConcept C150194340 @default.
- W2149309062 hasConcept C167734588 @default.
- W2149309062 hasConcept C170493617 @default.
- W2149309062 hasConcept C185592680 @default.
- W2149309062 hasConcept C2776914184 @default.
- W2149309062 hasConcept C2777025900 @default.
- W2149309062 hasConcept C2778229498 @default.
- W2149309062 hasConcept C2780559512 @default.