Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149313058> ?p ?o ?g. }
- W2149313058 endingPage "1873" @default.
- W2149313058 startingPage "1863" @default.
- W2149313058 abstract "During B lymphoid ontogeny, assembly of the pre-B cell receptor (BCR) is a principal developmental checkpoint at which several Src-related kinases may play redundant roles. Here the Src-related kinase Blk is shown to effect functions associated with the pre-BCR. B lymphoid expression of an active Blk mutant caused proliferation of B progenitor cells and enhanced responsiveness of these cells to interleukin 7. In mice lacking a functional pre-BCR, active Blk supported maturation beyond the pro-B cell stage, suppressed VH to DJH rearrangement, relieved selection for productive heavy chain rearrangement, and stimulated kappa rearrangement. These alterations were accompanied by tyrosine phosphorylation of immunoglobulin beta and Syk, as well as changes in gene expression consistent with developmental maturation. Thus, sustained activation of Blk induces responses normally associated with the pre-BCR." @default.
- W2149313058 created "2016-06-24" @default.
- W2149313058 creator A5003980178 @default.
- W2149313058 creator A5026873741 @default.
- W2149313058 creator A5033613116 @default.
- W2149313058 creator A5039646183 @default.
- W2149313058 date "2003-12-08" @default.
- W2149313058 modified "2023-09-23" @default.
- W2149313058 title "Mimicry of Pre–B Cell Receptor Signaling by Activation of the Tyrosine Kinase Blk" @default.
- W2149313058 cites W1536953298 @default.
- W2149313058 cites W1670107136 @default.
- W2149313058 cites W1969499881 @default.
- W2149313058 cites W1970663543 @default.
- W2149313058 cites W1972622005 @default.
- W2149313058 cites W1975289816 @default.
- W2149313058 cites W1976790385 @default.
- W2149313058 cites W1978389815 @default.
- W2149313058 cites W1981891742 @default.
- W2149313058 cites W1984678866 @default.
- W2149313058 cites W1988516522 @default.
- W2149313058 cites W1999697848 @default.
- W2149313058 cites W2010760683 @default.
- W2149313058 cites W2014395675 @default.
- W2149313058 cites W2022409371 @default.
- W2149313058 cites W2024791560 @default.
- W2149313058 cites W2026043938 @default.
- W2149313058 cites W2031263707 @default.
- W2149313058 cites W2032348735 @default.
- W2149313058 cites W2034006944 @default.
- W2149313058 cites W2035616122 @default.
- W2149313058 cites W2036068614 @default.
- W2149313058 cites W2036575265 @default.
- W2149313058 cites W2039132486 @default.
- W2149313058 cites W2046211031 @default.
- W2149313058 cites W2050205178 @default.
- W2149313058 cites W2055192078 @default.
- W2149313058 cites W2074238277 @default.
- W2149313058 cites W2075174748 @default.
- W2149313058 cites W2075675512 @default.
- W2149313058 cites W2079932405 @default.
- W2149313058 cites W2083010701 @default.
- W2149313058 cites W2087653208 @default.
- W2149313058 cites W2087947799 @default.
- W2149313058 cites W2088549138 @default.
- W2149313058 cites W2088741669 @default.
- W2149313058 cites W2096632716 @default.
- W2149313058 cites W2097830435 @default.
- W2149313058 cites W2119691249 @default.
- W2149313058 cites W2119947571 @default.
- W2149313058 cites W2126464081 @default.
- W2149313058 cites W2128449161 @default.
- W2149313058 cites W2134505654 @default.
- W2149313058 cites W2137058644 @default.
- W2149313058 cites W2139691510 @default.
- W2149313058 cites W2141445957 @default.
- W2149313058 cites W2142132827 @default.
- W2149313058 cites W2143603716 @default.
- W2149313058 cites W2146493685 @default.
- W2149313058 cites W2150038520 @default.
- W2149313058 cites W2150066505 @default.
- W2149313058 cites W2155988482 @default.
- W2149313058 cites W2159048899 @default.
- W2149313058 cites W2166588660 @default.
- W2149313058 cites W2167803680 @default.
- W2149313058 cites W2167863101 @default.
- W2149313058 cites W2168601978 @default.
- W2149313058 cites W232671765 @default.
- W2149313058 doi "https://doi.org/10.1084/jem.20030729" @default.
- W2149313058 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2194155" @default.
- W2149313058 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14662906" @default.
- W2149313058 hasPublicationYear "2003" @default.
- W2149313058 type Work @default.
- W2149313058 sameAs 2149313058 @default.
- W2149313058 citedByCount "65" @default.
- W2149313058 countsByYear W21493130582012 @default.
- W2149313058 countsByYear W21493130582013 @default.
- W2149313058 countsByYear W21493130582014 @default.
- W2149313058 countsByYear W21493130582015 @default.
- W2149313058 countsByYear W21493130582016 @default.
- W2149313058 countsByYear W21493130582017 @default.
- W2149313058 countsByYear W21493130582018 @default.
- W2149313058 countsByYear W21493130582019 @default.
- W2149313058 countsByYear W21493130582020 @default.
- W2149313058 countsByYear W21493130582021 @default.
- W2149313058 countsByYear W21493130582022 @default.
- W2149313058 countsByYear W21493130582023 @default.
- W2149313058 crossrefType "journal-article" @default.
- W2149313058 hasAuthorship W2149313058A5003980178 @default.
- W2149313058 hasAuthorship W2149313058A5026873741 @default.
- W2149313058 hasAuthorship W2149313058A5033613116 @default.
- W2149313058 hasAuthorship W2149313058A5039646183 @default.
- W2149313058 hasBestOaLocation W21493130581 @default.
- W2149313058 hasConcept C101544691 @default.
- W2149313058 hasConcept C11960822 @default.
- W2149313058 hasConcept C153911025 @default.
- W2149313058 hasConcept C157695867 @default.
- W2149313058 hasConcept C159654299 @default.
- W2149313058 hasConcept C170493617 @default.