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- W2149334560 abstract "Infection with Chlamydia pneumoniae has been implicated as a potential risk factor for atherosclerosis. This study was designed to investigate the mechanisms of the anti-chlamydial activity of aspirin. A reporter gene assay for NF-κB activity, immunoblot analysis for cyclo-oxygenase (COX)-2 and radioimmunoassay for prostaglandin E2 (PGE2) were performed. Following infection of HEp-2 cells with C. pneumoniae, NF-κB was activated, COX-2 was induced and PGE2 was elevated. Aspirin inhibited NF-κB activation at a concentration of 0.1 mM, partially inhibited COX-2 induction and blocked PGE2 synthesis completely. In addition, high doses of aspirin (1 and 2 mM) inhibited chlamydial growth in HEp-2 cells, decreasing the number and size of inclusion bodies; this effect could be overcome by adding tryptophan to the culture. Indomethacin also blocked the synthesis of PGE2, but had no effect on COX-2 expression or chlamydial growth. These results indicate that aspirin not only has an anti-inflammatory activity through prevention of NF-κB activation but also has anti-chlamydial activity at high doses, possibly through depletion of tryptophan in HEp-2 cells." @default.
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- W2149334560 date "2003-05-01" @default.
- W2149334560 modified "2023-09-23" @default.
- W2149334560 title "Aspirin inhibits Chlamydia pneumoniae-induced NF-κB activation, cyclo-oxygenase-2 expression and prostaglandin E2 synthesis and attenuates chlamydial growth" @default.
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- W2149334560 doi "https://doi.org/10.1099/jmm.0.04992-0" @default.
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