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• W2149336022 abstract "Significance Next-generation photodynamic therapy (NG-PDT) for the treatment of tumors preponderates over conventional practices in that it is a kind of effective precision medicine with minimal invasive procedures and side effects. Herein, a newly developed NG-PDT paradigm agent of gadolinium-porphyrin complex, Gd-N, is introduced, which can successfully trace and recognize tumor tissues via simple injection into the blood vessel of the mouse models, selectively accumulate within them, and superiorly exert the therapeutic effect via cytotoxic singlet oxygen generation (∼51% quantum yield) to eradicate the solid tumor by one-half within a short period of time only upon due two-photon excitation. Its characteristic two-photon–induced near-infrared emission is also always available for direct monitoring for transportation and effectiveness in vitro and in vivo." @default.
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• W2149336022 date "2014-12-01" @default.
• W2149336022 modified "2023-10-17" @default.
• W2149336022 title "In vivo selective cancer-tracking gadolinium eradicator as new-generation photodynamic therapy agent" @default.
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• W2149336022 doi "https://doi.org/10.1073/pnas.1414499111" @default.
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