FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149337508> ?p ?o ?g. }

• W2149337508 endingPage "1052" @default.
• W2149337508 startingPage "1039" @default.
• W2149337508 abstract "Mammalian sex chromosomes evolved from the degeneration of one homolog of a pair of ancestral autosomes, the proto-Y. This resulted in a gene dose imbalance that is believed to be restored (partially or fully) through upregulation of gene expression from the single active X-chromosome in both sexes by a dosage compensatory mechanism. We analyzed multiple genome-wide RNA stability data sets and found significantly longer average half-lives for X-chromosome transcripts than for autosomal transcripts in various human cell lines, both male and female, and in mice. Analysis of ribosome profiling data shows that ribosome density is higher on X-chromosome transcripts than on autosomal transcripts in both humans and mice, suggesting that the higher stability is causally linked to a higher translation rate. Our results and observations are in accordance with a dosage compensatory upregulation of expressed X-linked genes. We therefore propose that differential mRNA stability and translation rates of the autosomes and sex chromosomes contribute to an evolutionarily conserved dosage compensation mechanism in mammals." @default.
• W2149337508 created "2016-06-24" @default.
• W2149337508 creator A5062712474 @default.
• W2149337508 creator A5091224273 @default.
• W2149337508 date "2015-03-18" @default.
• W2149337508 modified "2023-09-25" @default.
• W2149337508 title "Increased Expression of X-Linked Genes in Mammals Is Associated with a Higher Stability of Transcripts and an Increased Ribosome Density" @default.
• W2149337508 cites W1825157170 @default.
• W2149337508 cites W1882252177 @default.
• W2149337508 cites W1965240564 @default.
• W2149337508 cites W1967016662 @default.
• W2149337508 cites W1981872287 @default.
• W2149337508 cites W1986396284 @default.
• W2149337508 cites W1992885695 @default.
• W2149337508 cites W1995931397 @default.
• W2149337508 cites W2002375443 @default.
• W2149337508 cites W2012862100 @default.
• W2149337508 cites W2013018983 @default.
• W2149337508 cites W2014759458 @default.
• W2149337508 cites W2017751411 @default.
• W2149337508 cites W2018445290 @default.
• W2149337508 cites W2019202989 @default.
• W2149337508 cites W2022636167 @default.
• W2149337508 cites W2026570544 @default.
• W2149337508 cites W2031041028 @default.
• W2149337508 cites W2033152634 @default.
• W2149337508 cites W2038662679 @default.
• W2149337508 cites W2043688054 @default.
• W2149337508 cites W2047962502 @default.
• W2149337508 cites W2054273086 @default.
• W2149337508 cites W2054411179 @default.
• W2149337508 cites W2056587430 @default.
• W2149337508 cites W2058972518 @default.
• W2149337508 cites W2059073003 @default.
• W2149337508 cites W2059282068 @default.
• W2149337508 cites W2060902122 @default.
• W2149337508 cites W2061851591 @default.
• W2149337508 cites W2064580380 @default.
• W2149337508 cites W2065847836 @default.
• W2149337508 cites W2072590456 @default.
• W2149337508 cites W2072770570 @default.
• W2149337508 cites W2077968912 @default.
• W2149337508 cites W2084585383 @default.
• W2149337508 cites W2085928743 @default.
• W2149337508 cites W2086399711 @default.
• W2149337508 cites W2087439897 @default.
• W2149337508 cites W2090191263 @default.
• W2149337508 cites W2091484949 @default.
• W2149337508 cites W2094583488 @default.
• W2149337508 cites W2105748760 @default.
• W2149337508 cites W2106619388 @default.
• W2149337508 cites W2110638928 @default.
• W2149337508 cites W2118235664 @default.
• W2149337508 cites W2120695614 @default.
• W2149337508 cites W2121186537 @default.
• W2149337508 cites W2121717006 @default.
• W2149337508 cites W2128551987 @default.
• W2149337508 cites W2128846766 @default.
• W2149337508 cites W2132452290 @default.
• W2149337508 cites W2133968430 @default.
• W2149337508 cites W2135277858 @default.
• W2149337508 cites W2136086657 @default.
• W2149337508 cites W2141805742 @default.
• W2149337508 cites W2143428306 @default.
• W2149337508 cites W2144012199 @default.
• W2149337508 cites W2152660247 @default.
• W2149337508 cites W2153973987 @default.
• W2149337508 cites W2155258325 @default.
• W2149337508 cites W2161053574 @default.
• W2149337508 cites W2161890613 @default.
• W2149337508 cites W2164131112 @default.
• W2149337508 cites W2170197653 @default.
• W2149337508 cites W4293003414 @default.
• W2149337508 doi "https://doi.org/10.1093/gbe/evv054" @default.
• W2149337508 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4419800" @default.
• W2149337508 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25786432" @default.
• W2149337508 hasPublicationYear "2015" @default.
• W2149337508 type Work @default.
• W2149337508 sameAs 2149337508 @default.
• W2149337508 citedByCount "27" @default.
• W2149337508 countsByYear W21493375082015 @default.
• W2149337508 countsByYear W21493375082016 @default.
• W2149337508 countsByYear W21493375082017 @default.
• W2149337508 countsByYear W21493375082018 @default.
• W2149337508 countsByYear W21493375082019 @default.
• W2149337508 countsByYear W21493375082020 @default.
• W2149337508 countsByYear W21493375082021 @default.
• W2149337508 countsByYear W21493375082022 @default.
• W2149337508 countsByYear W21493375082023 @default.
• W2149337508 crossrefType "journal-article" @default.
• W2149337508 hasAuthorship W2149337508A5062712474 @default.
• W2149337508 hasAuthorship W2149337508A5091224273 @default.
• W2149337508 hasBestOaLocation W21493375081 @default.
• W2149337508 hasConcept C104317684 @default.
• W2149337508 hasConcept C105580179 @default.
• W2149337508 hasConcept C134925867 @default.
• W2149337508 hasConcept C141231307 @default.
• W2149337508 hasConcept C149364088 @default.

• next