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• W2149339767 abstract "Nuclear factor E2-related factor 2 (nrf2) is accepted as an important transcription factor in the regulation of many phase II detoxifying enzymes and oxidative-stress-inducible genes in many tissues including bone and cartilage. However, little attention has been paid to precise role of nrf2 on osteoblasts and chondrocytes. In the present study, we therefore investigated the role of nrf2 in the regulation of cell proliferation, differentiation and maturation using both MC3T3-E1 and ATDC5 cells. In MC3T3-E1 cells stably transfected with nrf2 (MC3T3-E1-nrf2 clone), the differentiation-dependent induction of alkaline phosphatase activity was significantly inhibited in addition to decrease of the mineralized matrix formation. Moreover, expression of mRNAs for osteocalcin and type I collagen was also markedly attenuated in MC3T3E1-nrf2 clone but not in MC3T3E1-empty vector clone. These inhibitory effect on cell differentiation was also observed in ATDC5 cells stably transfected with nrf2. Moreover, nrf2 significantly impaired the runx2-dependent enhancement of osteocalcin promoter activity. These data suggest that nrf2 may negatively regulate the differentiation of both osteoblasts and chondrocytes through inhibition of the runx2 dependent transcriptional activity. . These are bone-forming osteoblasts and bone-resorbing osteoclasts. The osteoblast lineage is derived from primitive multipotent mesenchymal stem cells with potentiality to differentiate into bone marrow stromal cells, chondrocytes, muscles and adipocytes 3) , while osteoclasts are multinucleated cells derived from the fusion of mononuclear hematopoietic precursors 4) . The development and differentiation of these two distinct cells are under the tight regulation by a number of transcription factors. Among them, Runx2, a cell-specific member of the Runt family of transcription factors, play a pivotal role in osteoblastic differentiation. Runx2 is the earliest and most specific molecular marker of the osteoblast lineage, its expression is both necessary and sufficient to induce osteoblast differentiation, and it regulates expression of most genes characteristic of the osteoblast phenotype 5,6,7)" @default.
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• W2149339767 date "2005-01-01" @default.
• W2149339767 modified "2023-09-27" @default.
• W2149339767 title "nrf2 Expressed by Bone" @default.
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• W2149339767 doi "https://doi.org/10.2485/jhtb.14.280" @default.
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