FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149352307> ?p ?o ?g. }

• W2149352307 endingPage "8126" @default.
• W2149352307 startingPage "8112" @default.
• W2149352307 abstract "N-3 polyunsaturated fatty acids such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) have protective effects against atherosclerosis. Monocyte chemotactic protein (MCP)-1 is a major inflammatory mediator in the progression of atherosclerosis. However, little is known about the regulation of MCP-1 by DHA and EPA in vessels and vascular smooth muscle cells (VSMCs). In this study, we compared the effect of DHA and EPA on the expression of Mcp-1 in rat arterial strips and rat VSMCs. DHA, but not EPA, suppressed Mcp-1 expression in arterial strips. Furthermore, DHA generated 4-hydroxy hexenal (4-HHE), an end product of n-3 polyunsaturated fatty acids (PUFAs), in arterial strips as measured by liquid chromatography-tandem mass spectrometry. In addition, 4-HHE treatment suppressed Mcp-1 expression in arterial strips, suggesting 4-HHE derived from DHA may be involved in the mechanism of this phenomenon. In contrast, Mcp-1 expression was stimulated by DHA, EPA and 4-HHE through p38 kinase and the Keap1-Nuclear factor erythroid-derived 2-like 2 (Nrf2) pathway in VSMCs. In conclusion, there is a dual effect of n-3 PUFAs on the regulation of Mcp-1 expression. Further study is necessary to elucidate the pathological role of this phenomenon." @default.
• W2149352307 created "2016-06-24" @default.
• W2149352307 creator A5005118605 @default.
• W2149352307 creator A5007812621 @default.
• W2149352307 creator A5009215615 @default.
• W2149352307 creator A5037001617 @default.
• W2149352307 creator A5053317374 @default.
• W2149352307 creator A5054945728 @default.
• W2149352307 creator A5057391884 @default.
• W2149352307 creator A5058142995 @default.
• W2149352307 creator A5063103432 @default.
• W2149352307 creator A5069486431 @default.
• W2149352307 creator A5072922132 @default.
• W2149352307 creator A5079660874 @default.
• W2149352307 creator A5080877633 @default.
• W2149352307 creator A5084108759 @default.
• W2149352307 creator A5088284813 @default.
• W2149352307 date "2015-09-21" @default.
• W2149352307 modified "2023-09-26" @default.
• W2149352307 title "Duality of n-3 Polyunsaturated Fatty Acids on Mcp-1 Expression in Vascular Smooth Muscle: A Potential Role of 4-Hydroxy Hexenal" @default.
• W2149352307 cites W1530678958 @default.
• W2149352307 cites W1971004334 @default.
• W2149352307 cites W1982348792 @default.
• W2149352307 cites W1983782600 @default.
• W2149352307 cites W2003825529 @default.
• W2149352307 cites W2004815940 @default.
• W2149352307 cites W2009458118 @default.
• W2149352307 cites W2015862047 @default.
• W2149352307 cites W2016407358 @default.
• W2149352307 cites W2022515495 @default.
• W2149352307 cites W2031590544 @default.
• W2149352307 cites W2033262228 @default.
• W2149352307 cites W2034542419 @default.
• W2149352307 cites W2056980068 @default.
• W2149352307 cites W2070288514 @default.
• W2149352307 cites W2075902036 @default.
• W2149352307 cites W2090372317 @default.
• W2149352307 cites W2090522472 @default.
• W2149352307 cites W2094893408 @default.
• W2149352307 cites W2102353819 @default.
• W2149352307 cites W2107271450 @default.
• W2149352307 cites W2110248987 @default.
• W2149352307 cites W2113638285 @default.
• W2149352307 cites W2115889926 @default.
• W2149352307 cites W2119169375 @default.
• W2149352307 cites W2125762200 @default.
• W2149352307 cites W2131094572 @default.
• W2149352307 cites W2133340446 @default.
• W2149352307 cites W2138965761 @default.
• W2149352307 cites W2142681675 @default.
• W2149352307 cites W2163976499 @default.
• W2149352307 cites W2166102027 @default.
• W2149352307 cites W2167934388 @default.
• W2149352307 cites W2168526937 @default.
• W2149352307 cites W2325815717 @default.
• W2149352307 doi "https://doi.org/10.3390/nu7095381" @default.
• W2149352307 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4586576" @default.
• W2149352307 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26402697" @default.
• W2149352307 hasPublicationYear "2015" @default.
• W2149352307 type Work @default.
• W2149352307 sameAs 2149352307 @default.
• W2149352307 citedByCount "6" @default.
• W2149352307 countsByYear W21493523072016 @default.
• W2149352307 countsByYear W21493523072017 @default.
• W2149352307 countsByYear W21493523072018 @default.
• W2149352307 countsByYear W21493523072019 @default.
• W2149352307 countsByYear W21493523072022 @default.
• W2149352307 crossrefType "journal-article" @default.
• W2149352307 hasAuthorship W2149352307A5005118605 @default.
• W2149352307 hasAuthorship W2149352307A5007812621 @default.
• W2149352307 hasAuthorship W2149352307A5009215615 @default.
• W2149352307 hasAuthorship W2149352307A5037001617 @default.
• W2149352307 hasAuthorship W2149352307A5053317374 @default.
• W2149352307 hasAuthorship W2149352307A5054945728 @default.
• W2149352307 hasAuthorship W2149352307A5057391884 @default.
• W2149352307 hasAuthorship W2149352307A5058142995 @default.
• W2149352307 hasAuthorship W2149352307A5063103432 @default.
• W2149352307 hasAuthorship W2149352307A5069486431 @default.
• W2149352307 hasAuthorship W2149352307A5072922132 @default.
• W2149352307 hasAuthorship W2149352307A5079660874 @default.
• W2149352307 hasAuthorship W2149352307A5080877633 @default.
• W2149352307 hasAuthorship W2149352307A5084108759 @default.
• W2149352307 hasAuthorship W2149352307A5088284813 @default.
• W2149352307 hasBestOaLocation W21493523071 @default.
• W2149352307 hasConcept C126322002 @default.
• W2149352307 hasConcept C134018914 @default.
• W2149352307 hasConcept C185592680 @default.
• W2149352307 hasConcept C19038510 @default.
• W2149352307 hasConcept C2776016237 @default.
• W2149352307 hasConcept C2776091944 @default.
• W2149352307 hasConcept C2777171753 @default.
• W2149352307 hasConcept C2779395532 @default.
• W2149352307 hasConcept C2992686903 @default.
• W2149352307 hasConcept C515207424 @default.
• W2149352307 hasConcept C543025807 @default.
• W2149352307 hasConcept C55493867 @default.
• W2149352307 hasConcept C71924100 @default.
• W2149352307 hasConcept C86803240 @default.

• next