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• W2149358418 abstract "ABSTRACT MEF is an ETS-related transcription factor with strong transcriptional activating activity that affects hematopoietic stem cell behavior and is required for normal NK cell and NK T-cell development. The MEF (also known as ELF4) gene is repressed by several leukemia-associated fusion transcription factor proteins (PML-retinoic acid receptor α and AML1-ETO), but it is also activated by retroviral insertion in several cancer models. We have previously shown that cyclin A-dependent phosphorylation of MEF largely restricts its activity to the G 1 phase of the cell cycle; we now show that MEF is a short-lived protein whose expression level also peaks during late G 1 phase. Mutagenesis studies show that the rapid turnover of MEF in S phase is dependent on the specific phosphorylation of threonine 643 and serine 648 at the C terminus of MEF by cdk2 and on the Skp1/Cul1/F-box (SCF) E3 ubiquitin ligase complex SCF Skp2 , which targets MEF for ubiquitination and proteolysis. Overexpression of MEF drives cells through the G 1 /S transition, thereby promoting cell proliferation. The tight regulation of MEF levels during the cell cycle contributes to its effects on regulating cell cycle entry and cell proliferation." @default.
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• W2149358418 date "2006-04-15" @default.
• W2149358418 modified "2023-10-12" @default.
• W2149358418 title "The ETS Protein MEF Is Regulated by Phosphorylation-Dependent Proteolysis via the Protein-Ubiquitin Ligase SCF ^Skp2" @default.
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• W2149358418 doi "https://doi.org/10.1128/mcb.26.8.3114-3123.2006" @default.
• W2149358418 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1446966" @default.
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