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- W2149359249 abstract "Defects in apoptotic pathways can promote cancer development and cause cancers to become resistant to chemotherapy. The cell adhesion and signaling molecule PECAM-1 has been shown to potently suppress apoptosis in a variety of cellular systems. PECAM-1 expression has been reported on a variety of human malignancies—especially hematopoietic and vascular cell cancers—but the significance of this expression has not been fully explored. The ability of PECAM-1 to inhibit apoptosis makes it an attractive candidate as a molecule that may promote cancer development and/or confer resistance to chemotherapeutic treatment. The exact mechanisms by which PECAM-1 mediates its cytoprotection have not been fully defined, but its anti-apoptotic effects have been shown to require both homophilic binding and intracellular signaling via its immunoreceptor tyrosine-based inhibitory motif (ITIM) domains. In this review, we will discuss the data regarding PECAM-1's anti-apoptotic effects and ways in which this cytoprotection may be clinically relevant to the development and/or treatment of hematologic malignancies that express this vascular cell-specific surface molecule." @default.
- W2149359249 created "2016-06-24" @default.
- W2149359249 creator A5020694375 @default.
- W2149359249 creator A5031121462 @default.
- W2149359249 creator A5043749891 @default.
- W2149359249 date "2005-10-01" @default.
- W2149359249 modified "2023-09-26" @default.
- W2149359249 title "Mechanisms of PECAM-1-mediated cytoprotection and implications for cancer cell survival" @default.
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