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- W2149359491 endingPage "a010116" @default.
- W2149359491 startingPage "a010116" @default.
- W2149359491 abstract "The onset of genomic DNA synthesis requires precise interactions of specialized initiator proteins with DNA at sites where the replication machinery can be loaded. These sites, defined as replication origins, are found at a few unique locations in all of the prokaryotic chromosomes examined so far. However, replication origins are dispersed among tens of thousands of loci in metazoan chromosomes, thereby raising questions regarding the role of specific nucleotide sequences and chromatin environment in origin selection and the mechanisms used by initiators to recognize replication origins. Close examination of bacterial and archaeal replication origins reveals an array of DNA sequence motifs that position individual initiator protein molecules and promote initiator oligomerization on origin DNA. Conversely, the need for specific recognition sequences in eukaryotic replication origins is relaxed. In fact, the primary rule for origin selection appears to be flexibility, a feature that is modulated either by structural elements or by epigenetic mechanisms at least partly linked to the organization of the genome for gene expression." @default.
- W2149359491 created "2016-06-24" @default.
- W2149359491 creator A5013737080 @default.
- W2149359491 creator A5028741826 @default.
- W2149359491 date "2013-07-09" @default.
- W2149359491 modified "2023-10-14" @default.
- W2149359491 title "DNA Replication Origins" @default.
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