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- W2149360034 endingPage "230" @default.
- W2149360034 startingPage "219" @default.
- W2149360034 abstract "Cross-species transplantation (xenotransplantation) has immense potential to solve the critical need for organs, tissues and cells for clinical transplantation. The increasing availability of genetically engineered pigs is enabling progress to be made in pig-to-nonhuman primate experimental models. Potent pharmacologic immunosuppressive regimens have largely prevented T-cell rejection and a T-cell-dependent elicited antibody response. However, coagulation dysfunction between the pig and primate is proving to be a major problem, and this can result in life-threatening consumptive coagulopathy. This complication is unlikely to be overcome until pigs expressing a human 'antithrombotic' or 'anticoagulant' gene, such as thrombomodulin, tissue factor pathway inhibitor or CD39, become available. Progress in islet xenotransplantation has been more encouraging, and diabetes has been controlled in nonhuman primates for periods in excess of 6 months, although this has usually been achieved using immunosuppressive protocols that might not be clinically applicable. Further advances are required to overcome the remaining barriers." @default.
- W2149360034 created "2016-06-24" @default.
- W2149360034 creator A5018460898 @default.
- W2149360034 creator A5085492854 @default.
- W2149360034 date "2010-03-01" @default.
- W2149360034 modified "2023-10-14" @default.
- W2149360034 title "Overcoming the barriers to xenotransplantation: prospects for the future" @default.
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