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• W2149366307 abstract "Maternal diet can significantly skew the secondary sex ratio away from the expected value of 0.5 (proportion males), but the details of how diet may do this are unclear. Here, we altered dietary levels of salt (4% salt in the feed) and/or fructose (10% in the drinking water) of pregnant rats to model potential effects that consumption of a Western diet might have on maternofetal growth, development, and sex ratio. We demonstrate that excess fructose consumption before and during pregnancy lead to a marked skew in the secondary sex ratio (proportion of males, 0.60; P < 0.006). The effect was not mediated by selective developmental arrest of female embryos or influenced by fetal position in the uterine horn or sex-specific effects on sperm motility, suggesting a direct effect of glycolyzable monosaccharide on the maternal ovary and/or ovulated oocyte. Furthermore, combined excess maternal consumption of salt and fructose-sweetened beverage significantly reduced fertility, reflected as a 50% reduction in preimplantation and term litter size. In addition, we also noted birth order effects in the rat, with sequential implantation sites tending to be occupied by the same sex." @default.
• W2149366307 created "2016-06-24" @default.
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• W2149366307 date "2013-09-01" @default.
• W2149366307 modified "2023-10-01" @default.
• W2149366307 title "Maternal Fructose and/or Salt Intake and Reproductive Outcome in the Rat: Effects on Growth, Fertility, Sex Ratio, and Birth Order1" @default.
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• W2149366307 doi "https://doi.org/10.1095/biolreprod.113.109595" @default.
• W2149366307 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23759309" @default.
• W2149366307 hasPublicationYear "2013" @default.
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