FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149366474> ?p ?o ?g. }

• W2149366474 endingPage "1224" @default.
• W2149366474 startingPage "1215" @default.
• W2149366474 abstract "Downregulation of major histocompatibility complex (MHC) class I expression is an important mechanism by which tumors evade classical T cell-dependent immune responses. Therefore, a system was designed to evaluate parameters for active immunization against MHC class I- tumors. Mice were capable of rejecting a MHC class I- tumor challenge after immunization with an irradiated granulocyte/macrophage colony-stimulating factor (GM-CSF) transduced MHC class I- tumor vaccine. This response was critically dependent on CD4+ T cells and natural killer (NK) cells, but minimally on CD8+ T cells. A strong protective response against MHC class I+ variants of the tumor could be elicited when mice were immunized with irradiated MHC class I+ GM-CSF-secreting tumor cells. This response required CD4+ and CD8+ T cells, and in addition, elimination of NK cells resulted in outgrowth of tumors that had lost expression of at least one MHC class I gene. Finally, class I MHC expression on the vaccinating cells inhibited the response generated against a MHC class I- tumor challenge. These results demonstrate that the host is capable of being immunized against a tumor that has lost MHC class I expression and reveal conditions under which distinct effector cells play a role in the systemic antitumor immune response." @default.
• W2149366474 created "2016-06-24" @default.
• W2149366474 creator A5006860649 @default.
• W2149366474 creator A5013835186 @default.
• W2149366474 creator A5035916087 @default.
• W2149366474 creator A5066707073 @default.
• W2149366474 date "1994-04-01" @default.
• W2149366474 modified "2023-09-23" @default.
• W2149366474 title "In vivo priming of two distinct antitumor effector populations: the role of MHC class I expression." @default.
• W2149366474 cites W1521160613 @default.
• W2149366474 cites W1556867369 @default.
• W2149366474 cites W1560116787 @default.
• W2149366474 cites W1584719350 @default.
• W2149366474 cites W1600662889 @default.
• W2149366474 cites W1612135387 @default.
• W2149366474 cites W170775584 @default.
• W2149366474 cites W1831865193 @default.
• W2149366474 cites W1882808897 @default.
• W2149366474 cites W1931280869 @default.
• W2149366474 cites W1972450532 @default.
• W2149366474 cites W1973291904 @default.
• W2149366474 cites W1980621729 @default.
• W2149366474 cites W1990668606 @default.
• W2149366474 cites W1991148746 @default.
• W2149366474 cites W1994962756 @default.
• W2149366474 cites W2000583744 @default.
• W2149366474 cites W2004208692 @default.
• W2149366474 cites W2005765588 @default.
• W2149366474 cites W2006987944 @default.
• W2149366474 cites W2008564146 @default.
• W2149366474 cites W2009228522 @default.
• W2149366474 cites W2032724666 @default.
• W2149366474 cites W2035387224 @default.
• W2149366474 cites W2043091128 @default.
• W2149366474 cites W2046464172 @default.
• W2149366474 cites W2050531443 @default.
• W2149366474 cites W2052573499 @default.
• W2149366474 cites W2060333964 @default.
• W2149366474 cites W2077616485 @default.
• W2149366474 cites W2079627635 @default.
• W2149366474 cites W2088333719 @default.
• W2149366474 cites W2088513299 @default.
• W2149366474 cites W2091691801 @default.
• W2149366474 cites W2093698082 @default.
• W2149366474 cites W2102916120 @default.
• W2149366474 cites W2104417744 @default.
• W2149366474 cites W2133109711 @default.
• W2149366474 cites W2140843432 @default.
• W2149366474 cites W2143143209 @default.
• W2149366474 cites W2144429525 @default.
• W2149366474 cites W2150526928 @default.
• W2149366474 cites W2151113834 @default.
• W2149366474 cites W2180597555 @default.
• W2149366474 doi "https://doi.org/10.1084/jem.179.4.1215" @default.
• W2149366474 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2191440" @default.
• W2149366474 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7908321" @default.
• W2149366474 hasPublicationYear "1994" @default.
• W2149366474 type Work @default.
• W2149366474 sameAs 2149366474 @default.
• W2149366474 citedByCount "182" @default.
• W2149366474 countsByYear W21493664742012 @default.
• W2149366474 countsByYear W21493664742013 @default.
• W2149366474 countsByYear W21493664742014 @default.
• W2149366474 countsByYear W21493664742015 @default.
• W2149366474 countsByYear W21493664742016 @default.
• W2149366474 countsByYear W21493664742017 @default.
• W2149366474 countsByYear W21493664742018 @default.
• W2149366474 countsByYear W21493664742019 @default.
• W2149366474 countsByYear W21493664742020 @default.
• W2149366474 countsByYear W21493664742022 @default.
• W2149366474 countsByYear W21493664742023 @default.
• W2149366474 crossrefType "journal-article" @default.
• W2149366474 hasAuthorship W2149366474A5006860649 @default.
• W2149366474 hasAuthorship W2149366474A5013835186 @default.
• W2149366474 hasAuthorship W2149366474A5035916087 @default.
• W2149366474 hasAuthorship W2149366474A5066707073 @default.
• W2149366474 hasBestOaLocation W21493664741 @default.
• W2149366474 hasConcept C100701293 @default.
• W2149366474 hasConcept C129374314 @default.
• W2149366474 hasConcept C154317977 @default.
• W2149366474 hasConcept C167672396 @default.
• W2149366474 hasConcept C170627219 @default.
• W2149366474 hasConcept C202751555 @default.
• W2149366474 hasConcept C203014093 @default.
• W2149366474 hasConcept C207936829 @default.
• W2149366474 hasConcept C2778814158 @default.
• W2149366474 hasConcept C37386791 @default.
• W2149366474 hasConcept C502942594 @default.
• W2149366474 hasConcept C54355233 @default.
• W2149366474 hasConcept C59822182 @default.
• W2149366474 hasConcept C81444415 @default.
• W2149366474 hasConcept C86803240 @default.
• W2149366474 hasConcept C8891405 @default.
• W2149366474 hasConceptScore W2149366474C100701293 @default.
• W2149366474 hasConceptScore W2149366474C129374314 @default.
• W2149366474 hasConceptScore W2149366474C154317977 @default.
• W2149366474 hasConceptScore W2149366474C167672396 @default.
• W2149366474 hasConceptScore W2149366474C170627219 @default.

• next