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• W2149366901 abstract "Although comparison of RNA-protein interaction profiles across different conditions has become increasingly important to understanding the function of RNA-binding proteins (RBPs), few computational approaches have been developed for quantitative comparison of CLIP-seq datasets. Here, we present an easy-to-use command line tool, dCLIP, for quantitative CLIP-seq comparative analysis. The two-stage method implemented in dCLIP, including a modified MA normalization method and a hidden Markov model, is shown to be able to effectively identify differential binding regions of RBPs in four CLIP-seq datasets, generated by HITS-CLIP, iCLIP and PAR-CLIP protocols. dCLIP is freely available at http://qbrc.swmed.edu/software/." @default.
• W2149366901 created "2016-06-24" @default.
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• W2149366901 date "2014-01-01" @default.
• W2149366901 modified "2023-09-28" @default.
• W2149366901 title "dCLIP: a computational approach for comparative CLIP-seq analyses" @default.
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• W2149366901 doi "https://doi.org/10.1186/gb-2014-15-1-r11" @default.
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