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- W2149367169 abstract "ABSTRACT A hybrid protein [Met-Ala-(His) 6 OprF 190–342 -OprI 21–83 ] consisting of the mature outer membrane protein I (OprI) and amino acids 190 to 342 of OprF of Pseudomonas aeruginosa was expressed in Escherichia coli and purified by Ni 2+ chelate-affinity chromatography. After safety and pyrogenicity evaluations in animals, four groups of eight adult human volunteers were vaccinated intramuscularly three times at 4-week intervals and revaccinated 6 months later with either 500, 100, 50, or 20 μg of OprF-OprI adsorbed onto A1(OH) 3 . All vaccinations were well tolerated. After the first vaccination, a significant rise of antibody titers against P. aeruginosa OprF and OprI was measured in volunteers receiving the 100- or the 500-μg dose. After the second vaccination, significant antibody titers were measured for all groups. Elevated antibody titers against OprF and OprI could still be measured 6 months after the third vaccination. The capacity of the elicited antibodies to promote complement binding and opsonization could be demonstrated by a C1q-binding assay and by the in vitro opsonophagocytic uptake of P. aeruginosa bacteria. These data support the continued development of an OprF-OprI vaccine for use in humans." @default.
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- W2149367169 date "1999-03-01" @default.
- W2149367169 modified "2023-09-27" @default.
- W2149367169 title "Safety and Immunogenicity of a <i>Pseudomonas aeruginosa</i> Hybrid Outer Membrane Protein F-I Vaccine in Human Volunteers" @default.
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- W2149367169 doi "https://doi.org/10.1128/iai.67.3.1461-1470.1999" @default.
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