FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149372254> ?p ?o ?g. }

• W2149372254 endingPage "288" @default.
• W2149372254 startingPage "278" @default.
• W2149372254 abstract "Gemcitabine (Gemzar®) is the first line treatment for pancreatic cancer and often used in combination therapy for non-small cell lung, ovarian, and metastatic breast cancers. Although extremely toxic to a variety of tumor cells in culture, the clinical outcome of gemcitabine treatment still needs improvement. In the present study, a new gemcitabine nanoparticle formulation was developed by incorporating a previously reported stearic acid amide derivative of gemcitabine into nanoparticles prepared from lecithin/glyceryl monostearate-in-water emulsions. The stearoyl gemcitabine nanoparticles were cytotoxic to tumor cells in culture, although it took a longer time for the gemcitabine in the nanoparticles to kill tumor cells than for free gemcitabine. In mice with pre-established model mouse or human tumors, the stearoyl gemcitabine nanoparticles were significantly more effective than free gemcitabine in controlling the tumor growth. PEGylation of the gemcitabine nanoparticles with polyethylene glycol (2000) prolonged the circulation of the nanoparticles in blood and increased the accumulation of the nanoparticles in tumor tissues (>6-fold), but the PEGylated and un-PEGylated gemcitabine nanoparticles showed similar anti-tumor activity in mice. Nevertheless, the nanoparticle formulation was critical for the stearoyl gemcitabine to show a strong anti-tumor activity. It is concluded that for the gemcitabine derivate-containing nanoparticles, cytotoxicity data in culture may not be used to predict their in vivo anti-tumor activity, and this novel gemcitabine nanoparticle formulation has the potential to improve the clinical outcome of gemcitabine treatment." @default.
• W2149372254 created "2016-06-24" @default.
• W2149372254 creator A5003201262 @default.
• W2149372254 creator A5005329167 @default.
• W2149372254 creator A5013190172 @default.
• W2149372254 creator A5020637830 @default.
• W2149372254 creator A5042647297 @default.
• W2149372254 creator A5050114813 @default.
• W2149372254 creator A5068806952 @default.
• W2149372254 creator A5086525008 @default.
• W2149372254 creator A5087576156 @default.
• W2149372254 date "2011-05-01" @default.
• W2149372254 modified "2023-10-17" @default.
• W2149372254 title "In vitro and in vivo anti-tumor activities of a gemcitabine derivative carried by nanoparticles" @default.
• W2149372254 cites W152943885 @default.
• W2149372254 cites W1890647543 @default.
• W2149372254 cites W1931508686 @default.
• W2149372254 cites W1976070015 @default.
• W2149372254 cites W1982507788 @default.
• W2149372254 cites W1999503395 @default.
• W2149372254 cites W1999736153 @default.
• W2149372254 cites W2004787353 @default.
• W2149372254 cites W2027561558 @default.
• W2149372254 cites W2028697973 @default.
• W2149372254 cites W2033433322 @default.
• W2149372254 cites W2041727257 @default.
• W2149372254 cites W2041962423 @default.
• W2149372254 cites W2047419134 @default.
• W2149372254 cites W2063909696 @default.
• W2149372254 cites W2065991449 @default.
• W2149372254 cites W2077945404 @default.
• W2149372254 cites W2089001448 @default.
• W2149372254 cites W2092554910 @default.
• W2149372254 cites W2095287544 @default.
• W2149372254 cites W2132976759 @default.
• W2149372254 cites W2145214367 @default.
• W2149372254 cites W2161254114 @default.
• W2149372254 cites W2161419307 @default.
• W2149372254 doi "https://doi.org/10.1016/j.ijpharm.2011.02.037" @default.
• W2149372254 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3079786" @default.
• W2149372254 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21371545" @default.
• W2149372254 hasPublicationYear "2011" @default.
• W2149372254 type Work @default.
• W2149372254 sameAs 2149372254 @default.
• W2149372254 citedByCount "94" @default.
• W2149372254 countsByYear W21493722542012 @default.
• W2149372254 countsByYear W21493722542013 @default.
• W2149372254 countsByYear W21493722542014 @default.
• W2149372254 countsByYear W21493722542015 @default.
• W2149372254 countsByYear W21493722542016 @default.
• W2149372254 countsByYear W21493722542017 @default.
• W2149372254 countsByYear W21493722542018 @default.
• W2149372254 countsByYear W21493722542019 @default.
• W2149372254 countsByYear W21493722542020 @default.
• W2149372254 countsByYear W21493722542021 @default.
• W2149372254 countsByYear W21493722542022 @default.
• W2149372254 countsByYear W21493722542023 @default.
• W2149372254 crossrefType "journal-article" @default.
• W2149372254 hasAuthorship W2149372254A5003201262 @default.
• W2149372254 hasAuthorship W2149372254A5005329167 @default.
• W2149372254 hasAuthorship W2149372254A5013190172 @default.
• W2149372254 hasAuthorship W2149372254A5020637830 @default.
• W2149372254 hasAuthorship W2149372254A5042647297 @default.
• W2149372254 hasAuthorship W2149372254A5050114813 @default.
• W2149372254 hasAuthorship W2149372254A5068806952 @default.
• W2149372254 hasAuthorship W2149372254A5086525008 @default.
• W2149372254 hasAuthorship W2149372254A5087576156 @default.
• W2149372254 hasBestOaLocation W21493722542 @default.
• W2149372254 hasConcept C109316439 @default.
• W2149372254 hasConcept C126322002 @default.
• W2149372254 hasConcept C143998085 @default.
• W2149372254 hasConcept C150903083 @default.
• W2149372254 hasConcept C185592680 @default.
• W2149372254 hasConcept C202751555 @default.
• W2149372254 hasConcept C207001950 @default.
• W2149372254 hasConcept C2776694085 @default.
• W2149372254 hasConcept C2776964284 @default.
• W2149372254 hasConcept C2780258809 @default.
• W2149372254 hasConcept C502942594 @default.
• W2149372254 hasConcept C55493867 @default.
• W2149372254 hasConcept C71924100 @default.
• W2149372254 hasConcept C86803240 @default.
• W2149372254 hasConcept C98274493 @default.
• W2149372254 hasConceptScore W2149372254C109316439 @default.
• W2149372254 hasConceptScore W2149372254C126322002 @default.
• W2149372254 hasConceptScore W2149372254C143998085 @default.
• W2149372254 hasConceptScore W2149372254C150903083 @default.
• W2149372254 hasConceptScore W2149372254C185592680 @default.
• W2149372254 hasConceptScore W2149372254C202751555 @default.
• W2149372254 hasConceptScore W2149372254C207001950 @default.
• W2149372254 hasConceptScore W2149372254C2776694085 @default.
• W2149372254 hasConceptScore W2149372254C2776964284 @default.
• W2149372254 hasConceptScore W2149372254C2780258809 @default.
• W2149372254 hasConceptScore W2149372254C502942594 @default.
• W2149372254 hasConceptScore W2149372254C55493867 @default.
• W2149372254 hasConceptScore W2149372254C71924100 @default.
• W2149372254 hasConceptScore W2149372254C86803240 @default.
• W2149372254 hasConceptScore W2149372254C98274493 @default.

• next