FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149372808> ?p ?o ?g. }

• W2149372808 endingPage "84" @default.
• W2149372808 startingPage "75" @default.
• W2149372808 abstract "Congestive heart failure (CHF) is a common cause of atrial fibrillation (AF). Oxidative stress and inflammation (profibrotic) and peroxisome proliferator-activated receptor-alpha (PPAR-alpha, antifibrotic) factors may be involved in CHF-related remodeling. We evaluated the effects of simvastatin (antioxidant, anti-inflammatory) and fenofibrate (PPAR-alpha activator) on CHF-related atrial remodeling.Dogs were subjected to 2-week ventricular tachypacing (VTP) in the absence and presence of simvastatin (20 or 80 mg/day) or fenofibrate. Induced AF duration (DAF) was increased by VTP from 36+/-14 (non-paced controls) to 1005+/-257 s (p<0.01). Simvastatin prevented VTP-induced DAF increases (147+/-37 and 84+/-37 s at 20 and 80 mg/day, respectively), but fenofibrate did not (1018+/-352 s). Simvastatin also attenuated CHF-induced conduction abnormalities (heterogeneity-index reduced from 1.5+/-0.1 to 1.1+/-0.1 and 1.0+/-0.1 at 20 and 80 mg/day, p<0.01) and atrial fibrosis (from 19.4+/-1.3% to 10.8+/-0.8% and 9.9+/-0.8% at 20 and 80 mg/day, p<0.01), while fenofibrate did not. Simvastatin (but not fenofibrate) also attenuated VTP-induced left-ventricular nitric-oxide synthase and nitrotyrosine increases, along with hemodynamic dysfunction. Atrial fibroblast proliferation increased with 24-h fetal bovine serum (FBS) stimulation from 654+/-153 to 7264+/-1636 DPM (p<0.001). Simvastatin, but not fenofibrate, suppressed fibroblast proliferation (664+/-192 DPM, p<0.001). Simvastatin also significantly attenuated transforming growth factor-beta1-stimulated alpha-smooth muscle actin (alpha-SMA) expression (indicating myofibroblast differentiation) from 1.3+/-0.1 to 1.0+/-0.1 times baseline (p<0.05).CHF-induced atrial structural remodeling and AF promotion are attenuated by simvastatin, but not fenofibrate. Statin-induced inhibition of profibrotic atrial fibroblast responses and attenuation of left-ventricular dysfunction may contribute to preventing the CHF-induced fibrotic AF substrate." @default.
• W2149372808 created "2016-06-24" @default.
• W2149372808 creator A5035027228 @default.
• W2149372808 creator A5054206623 @default.
• W2149372808 creator A5060685137 @default.
• W2149372808 creator A5061431109 @default.
• W2149372808 creator A5064311226 @default.
• W2149372808 creator A5066866386 @default.
• W2149372808 creator A5080051730 @default.
• W2149372808 date "2007-04-01" @default.
• W2149372808 modified "2023-10-05" @default.
• W2149372808 title "Effects of simvastatin on the development of the atrial fibrillation substrate in dogs with congestive heart failure☆" @default.
• W2149372808 cites W1671834350 @default.
• W2149372808 cites W1964636436 @default.
• W2149372808 cites W1967970013 @default.
• W2149372808 cites W1972253696 @default.
• W2149372808 cites W1973523151 @default.
• W2149372808 cites W1977666051 @default.
• W2149372808 cites W1986680773 @default.
• W2149372808 cites W1992540727 @default.
• W2149372808 cites W1996462984 @default.
• W2149372808 cites W2003406489 @default.
• W2149372808 cites W2003427415 @default.
• W2149372808 cites W2007883033 @default.
• W2149372808 cites W2015639803 @default.
• W2149372808 cites W2038843437 @default.
• W2149372808 cites W2039617287 @default.
• W2149372808 cites W2051441972 @default.
• W2149372808 cites W2056257969 @default.
• W2149372808 cites W2058986936 @default.
• W2149372808 cites W2065447230 @default.
• W2149372808 cites W2081813895 @default.
• W2149372808 cites W2088742606 @default.
• W2149372808 cites W2091146995 @default.
• W2149372808 cites W2091653450 @default.
• W2149372808 cites W2098924056 @default.
• W2149372808 cites W2099834627 @default.
• W2149372808 cites W2102858052 @default.
• W2149372808 cites W2106741130 @default.
• W2149372808 cites W2112893975 @default.
• W2149372808 cites W2116062937 @default.
• W2149372808 cites W2120194464 @default.
• W2149372808 cites W2120386224 @default.
• W2149372808 cites W2120649473 @default.
• W2149372808 cites W2125603290 @default.
• W2149372808 cites W2126500397 @default.
• W2149372808 cites W2127818427 @default.
• W2149372808 cites W2128752709 @default.
• W2149372808 cites W2129246481 @default.
• W2149372808 cites W2131043085 @default.
• W2149372808 cites W2134275449 @default.
• W2149372808 cites W2137712934 @default.
• W2149372808 cites W2142480862 @default.
• W2149372808 cites W2147918774 @default.
• W2149372808 cites W2148168402 @default.
• W2149372808 cites W2149015989 @default.
• W2149372808 cites W2152926085 @default.
• W2149372808 cites W2153011273 @default.
• W2149372808 cites W2154818940 @default.
• W2149372808 cites W2155291977 @default.
• W2149372808 cites W2157922331 @default.
• W2149372808 cites W2158880436 @default.
• W2149372808 cites W2164029652 @default.
• W2149372808 cites W2164825231 @default.
• W2149372808 cites W2169813623 @default.
• W2149372808 cites W2171466485 @default.
• W2149372808 doi "https://doi.org/10.1016/j.cardiores.2007.01.002" @default.
• W2149372808 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17270161" @default.
• W2149372808 hasPublicationYear "2007" @default.
• W2149372808 type Work @default.
• W2149372808 sameAs 2149372808 @default.
• W2149372808 citedByCount "143" @default.
• W2149372808 countsByYear W21493728082012 @default.
• W2149372808 countsByYear W21493728082013 @default.
• W2149372808 countsByYear W21493728082014 @default.
• W2149372808 countsByYear W21493728082015 @default.
• W2149372808 countsByYear W21493728082016 @default.
• W2149372808 countsByYear W21493728082017 @default.
• W2149372808 countsByYear W21493728082018 @default.
• W2149372808 countsByYear W21493728082019 @default.
• W2149372808 countsByYear W21493728082020 @default.
• W2149372808 countsByYear W21493728082021 @default.
• W2149372808 countsByYear W21493728082022 @default.
• W2149372808 crossrefType "journal-article" @default.
• W2149372808 hasAuthorship W2149372808A5035027228 @default.
• W2149372808 hasAuthorship W2149372808A5054206623 @default.
• W2149372808 hasAuthorship W2149372808A5060685137 @default.
• W2149372808 hasAuthorship W2149372808A5061431109 @default.
• W2149372808 hasAuthorship W2149372808A5064311226 @default.
• W2149372808 hasAuthorship W2149372808A5066866386 @default.
• W2149372808 hasAuthorship W2149372808A5080051730 @default.
• W2149372808 hasBestOaLocation W21493728081 @default.
• W2149372808 hasConcept C126322002 @default.
• W2149372808 hasConcept C134018914 @default.
• W2149372808 hasConcept C2776329913 @default.
• W2149372808 hasConcept C2777622882 @default.
• W2149372808 hasConcept C2778110834 @default.
• W2149372808 hasConcept C2778198053 @default.

• next