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- W2149382143 abstract "A new fipronil-based spot-on formulation applied once to dogs was evaluated against experimentalflea infestations in a parallel group design, randomized, unicentre and blinded controlled study. Eightdogs served as negative controls (group 1), eight dogs were treated with a 10% w/v fipronil-basedspot-on solution (Effipro® Spot-on, Virbac SA) at a dosage of 0.67 mL for a dog weighing from 2 to 10kg and 1.34 mL for a dog weighing from 10.1 to 20 kg (group 2) and eight dogs served as positivecontrols (group 3) receiving the original fipronil spot-on (Frontline® Top spot, Merial) at a similardosage. Each dog was infested with 100 unfed adult Ctenocephalides felis on days -6, -1, 7, 14, 21, 28,35, 42, 49, 56, 63, 70, 77, 84 and 91. At 48 h after treatment or re-infestation, each dog was combedto remove and count live fleas. Geometric mean flea counts obtained were reduced by 99.7 and100% in groups 2 and 3, respectively on day 2, compared to the negative control group. Dogs wereprotected from re-infestations with an efficacy >95 per cent for 93 days in group 2 and for 79 days ingroup 3. Both 10% w/v fipronil-based spot-ons, despite different vehicles, were equally able toeradicate flea infestation, to prevent new infestations and were well-tolerated." @default.
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- W2149382143 date "2010-01-01" @default.
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- W2149382143 title "Comparative efficacy of two fipronil spot-on formulations against experimental flea infestations (Ctenocephalides felis) in dogs." @default.
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