FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149382712> ?p ?o ?g. }

• W2149382712 endingPage "12" @default.
• W2149382712 startingPage "1" @default.
• W2149382712 abstract "Understanding the molecular mechanisms underlying diabetic endothelial dysfunction is necessary in order to improve the cardiovascular health of diabetic patients. Previously, we described an in vivo , murine model of insulin resistance induced by feeding a high-fat diet (HFD) whereby the endothelium may be isolated by fluorescence-activated cell sorting (FACS) based on Tie2-GFP expression and cell-surface staining. Here, we apply this model to two new strains of mice, ScN/Tie2-GFP and ApoE (−/−)/Tie2-GFP, and describe their metabolic responses and endothelial isolation. ScN/Tie2-GFP mice, which lack a functional toll-like receptor 4 (TLR4), display lower fasting glucose and insulin levels and improved glucose tolerance compared to Tie2-GFP mice, suggesting that TLR4 deficiency decreases susceptibility to the development of insulin resistance. ApoE (−/−)/Tie2-GFP mice display elevated glucose and cholesterol levels versus Tie2-GFP mice. Endothelial isolation by FACS achieves a pure population of endothelial cells that retain GFP fluorescence and endothelial functions. Transcriptional analysis of the aortic and muscle endothelium isolated from ApoE (−/−)/Tie2-GFP mice reveals a reduced endothelial response to HFD compared to Tie2-GFP mice, perhaps resulting from preexisting endothelial dysfunction in the hypercholesterolemic state. These mouse models and endothelial isolation techniques are valuable for assessing diabetic endothelial dysfunction and vascular responses in vivo ." @default.
• W2149382712 created "2016-06-24" @default.
• W2149382712 creator A5017179344 @default.
• W2149382712 creator A5024281012 @default.
• W2149382712 creator A5080888649 @default.
• W2149382712 date "2013-06-11" @default.
• W2149382712 modified "2023-10-15" @default.
• W2149382712 title "Mouse Models and Techniques for the Isolation of the Diabetic Endothelium" @default.
• W2149382712 cites W1886764071 @default.
• W2149382712 cites W1969615558 @default.
• W2149382712 cites W1979598489 @default.
• W2149382712 cites W1979617511 @default.
• W2149382712 cites W1983774854 @default.
• W2149382712 cites W1991061419 @default.
• W2149382712 cites W1998287845 @default.
• W2149382712 cites W1998628654 @default.
• W2149382712 cites W2027654614 @default.
• W2149382712 cites W2033457158 @default.
• W2149382712 cites W2054106960 @default.
• W2149382712 cites W2073935170 @default.
• W2149382712 cites W2080678317 @default.
• W2149382712 cites W2105169620 @default.
• W2149382712 cites W2124109795 @default.
• W2149382712 cites W2127902125 @default.
• W2149382712 cites W2134254489 @default.
• W2149382712 cites W2145437385 @default.
• W2149382712 cites W2153321120 @default.
• W2149382712 cites W2171783221 @default.
• W2149382712 cites W2279479268 @default.
• W2149382712 cites W4317707609 @default.
• W2149382712 doi "https://doi.org/10.1155/2013/165397" @default.
• W2149382712 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3693106" @default.
• W2149382712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23840960" @default.
• W2149382712 hasPublicationYear "2013" @default.
• W2149382712 type Work @default.
• W2149382712 sameAs 2149382712 @default.
• W2149382712 citedByCount "3" @default.
• W2149382712 countsByYear W21493827122015 @default.
• W2149382712 countsByYear W21493827122019 @default.
• W2149382712 countsByYear W21493827122020 @default.
• W2149382712 crossrefType "journal-article" @default.
• W2149382712 hasAuthorship W2149382712A5017179344 @default.
• W2149382712 hasAuthorship W2149382712A5024281012 @default.
• W2149382712 hasAuthorship W2149382712A5080888649 @default.
• W2149382712 hasBestOaLocation W21493827121 @default.
• W2149382712 hasConcept C104317684 @default.
• W2149382712 hasConcept C123012128 @default.
• W2149382712 hasConcept C126322002 @default.
• W2149382712 hasConcept C134018914 @default.
• W2149382712 hasConcept C142613039 @default.
• W2149382712 hasConcept C202751555 @default.
• W2149382712 hasConcept C203014093 @default.
• W2149382712 hasConcept C2776992346 @default.
• W2149382712 hasConcept C2777391703 @default.
• W2149382712 hasConcept C2778630268 @default.
• W2149382712 hasConcept C2779306644 @default.
• W2149382712 hasConcept C2780394083 @default.
• W2149382712 hasConcept C2780972559 @default.
• W2149382712 hasConcept C2908647359 @default.
• W2149382712 hasConcept C553184892 @default.
• W2149382712 hasConcept C55493867 @default.
• W2149382712 hasConcept C71924100 @default.
• W2149382712 hasConcept C85219853 @default.
• W2149382712 hasConcept C86803240 @default.
• W2149382712 hasConcept C95444343 @default.
• W2149382712 hasConcept C99454951 @default.
• W2149382712 hasConceptScore W2149382712C104317684 @default.
• W2149382712 hasConceptScore W2149382712C123012128 @default.
• W2149382712 hasConceptScore W2149382712C126322002 @default.
• W2149382712 hasConceptScore W2149382712C134018914 @default.
• W2149382712 hasConceptScore W2149382712C142613039 @default.
• W2149382712 hasConceptScore W2149382712C202751555 @default.
• W2149382712 hasConceptScore W2149382712C203014093 @default.
• W2149382712 hasConceptScore W2149382712C2776992346 @default.
• W2149382712 hasConceptScore W2149382712C2777391703 @default.
• W2149382712 hasConceptScore W2149382712C2778630268 @default.
• W2149382712 hasConceptScore W2149382712C2779306644 @default.
• W2149382712 hasConceptScore W2149382712C2780394083 @default.
• W2149382712 hasConceptScore W2149382712C2780972559 @default.
• W2149382712 hasConceptScore W2149382712C2908647359 @default.
• W2149382712 hasConceptScore W2149382712C553184892 @default.
• W2149382712 hasConceptScore W2149382712C55493867 @default.
• W2149382712 hasConceptScore W2149382712C71924100 @default.
• W2149382712 hasConceptScore W2149382712C85219853 @default.
• W2149382712 hasConceptScore W2149382712C86803240 @default.
• W2149382712 hasConceptScore W2149382712C95444343 @default.
• W2149382712 hasConceptScore W2149382712C99454951 @default.
• W2149382712 hasFunder F4320332161 @default.
• W2149382712 hasLocation W21493827121 @default.
• W2149382712 hasLocation W21493827122 @default.
• W2149382712 hasLocation W21493827123 @default.
• W2149382712 hasLocation W21493827124 @default.
• W2149382712 hasOpenAccess W2149382712 @default.
• W2149382712 hasPrimaryLocation W21493827121 @default.
• W2149382712 hasRelatedWork W138803513 @default.
• W2149382712 hasRelatedWork W1986132654 @default.
• W2149382712 hasRelatedWork W2010140898 @default.
• W2149382712 hasRelatedWork W2010484394 @default.

• next