Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149389098> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2149389098 abstract "Chronic viral hepatitis B remains a global public health concern. Currently, several drugs, such as lamivudine and telbivudine, are recommended for treatment of patients with chronic hepatitis B. However, there are no conclusive results on the comparison of the efficacy of lamivudine (LAM) and telbivudine (LdT) in the treatment of chronic hepatitis B.To evaluate the comparison of the efficacy of LAM and LdT in the treatment of chronic hepatitis B by a systematic review and meta-analysis of clinical trials, we searched PUBMED (from 1990 to April 2010), Web of Science (from 1990 to April 2010), EMBASE (from 1990 to April 2010), CNKI (National Knowledge Infrastructure) (from 1990 to April 2010), VIP database (from 1990 to April 2010), WANFANG database (from 1990 to April 2010), the Cochrane Central Register of Controlled Trials and the Cochrane Database of Systematic Review. At the end of one-year treatment, LdT was better than LAM at the biochemical response, virological response, HBeAg loss, therapeutic response, while less than at the viral breakthrough and viral resistance, but there was no significant difference in the HBeAg seroconversion and HBsAg response. LdT was better than LAM at the HBeAg seroconversion with prolonged treatment to two years.In summary, LdT was superior in inhibiting HBV replication and preventing drug resistance as compared to LAM for CHB patients. But LdT may cause more nonspecific adverse events and can lead to more CK elevation than LAM. It is thus recommended that the LdT could be used as an option for patients but adverse events, for example CK elevation, must be monitored." @default.
- W2149389098 created "2016-06-24" @default.
- W2149389098 creator A5001131086 @default.
- W2149389098 creator A5031080263 @default.
- W2149389098 creator A5051886373 @default.
- W2149389098 creator A5059947196 @default.
- W2149389098 creator A5075716007 @default.
- W2149389098 creator A5082468343 @default.
- W2149389098 date "2010-09-03" @default.
- W2149389098 modified "2023-09-27" @default.
- W2149389098 title "Comparison of the efficacy of lamivudine and telbivudine in the treatment of chronic hepatitis B: a systematic review" @default.
- W2149389098 cites W1986215651 @default.
- W2149389098 cites W1989935586 @default.
- W2149389098 cites W2000336618 @default.
- W2149389098 cites W2005440155 @default.
- W2149389098 cites W2018076560 @default.
- W2149389098 cites W2027543203 @default.
- W2149389098 cites W2033890227 @default.
- W2149389098 cites W2062680879 @default.
- W2149389098 cites W2062905914 @default.
- W2149389098 cites W2081954973 @default.
- W2149389098 cites W2083725441 @default.
- W2149389098 cites W2087564721 @default.
- W2149389098 cites W2089829494 @default.
- W2149389098 cites W2101299963 @default.
- W2149389098 cites W2145285067 @default.
- W2149389098 cites W4247967755 @default.
- W2149389098 doi "https://doi.org/10.1186/1743-422x-7-211" @default.
- W2149389098 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2939564" @default.
- W2149389098 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20815890" @default.
- W2149389098 hasPublicationYear "2010" @default.
- W2149389098 type Work @default.
- W2149389098 sameAs 2149389098 @default.
- W2149389098 citedByCount "19" @default.
- W2149389098 countsByYear W21493890982012 @default.
- W2149389098 countsByYear W21493890982013 @default.
- W2149389098 countsByYear W21493890982014 @default.
- W2149389098 countsByYear W21493890982015 @default.
- W2149389098 countsByYear W21493890982017 @default.
- W2149389098 countsByYear W21493890982019 @default.
- W2149389098 countsByYear W21493890982021 @default.
- W2149389098 crossrefType "journal-article" @default.
- W2149389098 hasAuthorship W2149389098A5001131086 @default.
- W2149389098 hasAuthorship W2149389098A5031080263 @default.
- W2149389098 hasAuthorship W2149389098A5051886373 @default.
- W2149389098 hasAuthorship W2149389098A5059947196 @default.
- W2149389098 hasAuthorship W2149389098A5075716007 @default.
- W2149389098 hasAuthorship W2149389098A5082468343 @default.
- W2149389098 hasBestOaLocation W21493890981 @default.
- W2149389098 hasConcept C126322002 @default.
- W2149389098 hasConcept C159047783 @default.
- W2149389098 hasConcept C197934379 @default.
- W2149389098 hasConcept C203014093 @default.
- W2149389098 hasConcept C2522874641 @default.
- W2149389098 hasConcept C2775940106 @default.
- W2149389098 hasConcept C2777382497 @default.
- W2149389098 hasConcept C2777410769 @default.
- W2149389098 hasConcept C2777451964 @default.
- W2149389098 hasConcept C2777869810 @default.
- W2149389098 hasConcept C2780593183 @default.
- W2149389098 hasConcept C2781144229 @default.
- W2149389098 hasConcept C71924100 @default.
- W2149389098 hasConceptScore W2149389098C126322002 @default.
- W2149389098 hasConceptScore W2149389098C159047783 @default.
- W2149389098 hasConceptScore W2149389098C197934379 @default.
- W2149389098 hasConceptScore W2149389098C203014093 @default.
- W2149389098 hasConceptScore W2149389098C2522874641 @default.
- W2149389098 hasConceptScore W2149389098C2775940106 @default.
- W2149389098 hasConceptScore W2149389098C2777382497 @default.
- W2149389098 hasConceptScore W2149389098C2777410769 @default.
- W2149389098 hasConceptScore W2149389098C2777451964 @default.
- W2149389098 hasConceptScore W2149389098C2777869810 @default.
- W2149389098 hasConceptScore W2149389098C2780593183 @default.
- W2149389098 hasConceptScore W2149389098C2781144229 @default.
- W2149389098 hasConceptScore W2149389098C71924100 @default.
- W2149389098 hasIssue "1" @default.
- W2149389098 hasLocation W21493890981 @default.
- W2149389098 hasLocation W21493890982 @default.
- W2149389098 hasLocation W21493890983 @default.
- W2149389098 hasLocation W21493890984 @default.
- W2149389098 hasOpenAccess W2149389098 @default.
- W2149389098 hasPrimaryLocation W21493890981 @default.
- W2149389098 hasRelatedWork W1556816728 @default.
- W2149389098 hasRelatedWork W2050694322 @default.
- W2149389098 hasRelatedWork W2061734351 @default.
- W2149389098 hasRelatedWork W2164269826 @default.
- W2149389098 hasRelatedWork W2382375426 @default.
- W2149389098 hasRelatedWork W2603778119 @default.
- W2149389098 hasRelatedWork W2953442664 @default.
- W2149389098 hasRelatedWork W3031056812 @default.
- W2149389098 hasRelatedWork W3152227415 @default.
- W2149389098 hasRelatedWork W4328054294 @default.
- W2149389098 hasVolume "7" @default.
- W2149389098 isParatext "false" @default.
- W2149389098 isRetracted "false" @default.
- W2149389098 magId "2149389098" @default.
- W2149389098 workType "article" @default.