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- W2149398002 abstract "Cortistatin (CST) is a recently described neuropeptide that shares high homology with somatostatin (somatotropin release-inhibiting factor, SRIF) and binds with high affinity to all somatostatin (sst) receptor subtypes. CST is currently known to have a widespread distribution in many human organs including the immune system. The activities specific to CST may be partially attributable to its binding to the growth hormone secretagogue (GHS)-receptor (GHS-R) and the orphan G-protein-coupled receptor MrgX2. Human immune cells produce CST, whereas macrophage lineage and activated endothelium express sst2, and human lymphocytes express sst3. The human thymus expresses sst1, 2, 3, MrgX2 and almost all immune cells express GHS-R. Moreover, at this very moment promising research with CST in experimental animal models is being performed. On the basis of these promising results, studies aiming to further evaluate the possibilities of CST as a therapeutic agent in human immune-mediated inflammatory diseases are warranted." @default.
- W2149398002 created "2016-06-24" @default.
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- W2149398002 creator A5016878392 @default.
- W2149398002 creator A5026793311 @default.
- W2149398002 creator A5029370761 @default.
- W2149398002 date "2008-05-01" @default.
- W2149398002 modified "2023-10-07" @default.
- W2149398002 title "The role of cortistatin in the human immune system" @default.
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- W2149398002 doi "https://doi.org/10.1016/j.mce.2008.03.007" @default.
- W2149398002 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18450367" @default.
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