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• W2149407988 abstract "Recent studies suggest that some RNA-binding proteins facilitate the folding of non-cognate RNAs. Here, we report that bacteriophage MS2 coat protein (MS2 CP) bound and promoted the catalytic activity of Candida group I ribozyme. Cloning of the MS2-bound RNA segments showed that this protein primarily interacts with the P5ab-P5 structure. Ultraviolet cross-linking and the T1 footprinting assay further showed that MS2 binding stabilized tertiary interactions, including the conserved L9-P5 interaction, and led to a more compact core structure. This mechanism is similar to that of the yeast mitochondrial tyrosyl-tRNA synthetase on other group I introns, suggesting that different RNA-binding proteins may use common mechanisms to support RNA structures." @default.
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• W2149407988 date "2009-01-01" @default.
• W2149407988 modified "2023-10-14" @default.
• W2149407988 title "A phage RNA-binding protein binds to a non-cognate structured RNA and stabilizes its core structure" @default.
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• W2149407988 doi "https://doi.org/10.1016/j.bbrc.2008.10.160" @default.
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