FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149409034> ?p ?o ?g. }

• W2149409034 endingPage "1025" @default.
• W2149409034 startingPage "1019" @default.
• W2149409034 abstract "VPAC1 encodes G-protein-coupled receptors expressed on all breast cancer (BC) cells at the onset of the disease, but not on benign lesions. Our extensive preclinical studies have shown that (64)Cu-TP3805 has a high affinity for VPAC1, is stable in vivo, and has the ability to distinguish spontaneously grown malignant BC masses from benign lesions. Our long-term goal is to develop (64)Cu-TP3805 as an agent to perform in vivo histology, to distinguish malignant lesions from benign masses noninvasively and thereby avoid patient morbidity and the excess economic costs of benign biopsies.(18)F-FDG obtained commercially served as a control. (64)Cu-TP3805 was prepared using a sterile kit containing 20 μg of TP3805. Radiochemical purity and sterility were examined. Nineteen consenting women with histologically proven BC were given 370 MBq of (18)F-FDG. One hour later, 6 of these patients were imaged with PET/CT and 13 with positron emission mammography (PEM). Two to 7 d later, 6 PET/CT patients received 111 MBq (± 10%) (n = 2), 127 MBq (± 10%) (n = 2), or 148 MBq (± 10%) (n = 2) of (64)Cu-TP3805 and were imaged 2 and 4 h later. Thirteen PEM patients received 148 MBq (± 10%) of (64)Cu-TP3805 and were imaged 15 min, 1 h, 2 h, and 4 h later. Standardized uptake value (SUV) was calculated for PET/CT patients, and PUV/BGV (PEM uptake value/background value) was calculated for PEM patients. Tumor volume was also calculated.The radiochemical purity of (64)Cu-TP3805 was 97% ± 2%, and specific activity was 44.4 GBq (1.2 Ci)/μmol. In 19 patients, a total of 24 lesions were imaged (15 invasive ductal carcinoma, 1 high-grade mammary carcinoma, 3 lobular carcinoma, 1 invasive papilloma, and 4 sentinel lymph nodes). All lesions were unequivocally detected by (64)Cu-TP3805 and by (18)F-FDG. The average tumor volume as determined by PET/CT with (64)Cu-TP3805 was 90.6% ± 16.1% of that with (18)F-FDG PET/CT, and the average SUV was 92% ± 26.4% of that with (18)F-FDG. For PEM, the tumor volume with (64)Cu-TP3805 was 113% ± 37% of that with (18)F-FDG and the PUV/BGV ratio was 97.7% ± 24.5% of that with (18)F-FDG.(64)Cu-TP3805 is worthy of further investigation in patients requiring biopsy of suggestive imaging findings, to further evaluate its ability to distinguish malignant lesions from benign masses noninvasively." @default.
• W2149409034 created "2016-06-24" @default.
• W2149409034 creator A5017725276 @default.
• W2149409034 creator A5018474662 @default.
• W2149409034 creator A5021531753 @default.
• W2149409034 creator A5024369884 @default.
• W2149409034 creator A5048335522 @default.
• W2149409034 creator A5069167592 @default.
• W2149409034 creator A5082309424 @default.
• W2149409034 creator A5086255780 @default.
• W2149409034 creator A5090922693 @default.
• W2149409034 date "2013-05-07" @default.
• W2149409034 modified "2023-10-15" @default.
• W2149409034 title "VPAC1 Receptors for Imaging Breast Cancer: A Feasibility Study" @default.
• W2149409034 cites W1966703965 @default.
• W2149409034 cites W1987192010 @default.
• W2149409034 cites W1993098727 @default.
• W2149409034 cites W1995396954 @default.
• W2149409034 cites W2003188860 @default.
• W2149409034 cites W2015893497 @default.
• W2149409034 cites W2018359558 @default.
• W2149409034 cites W2018864714 @default.
• W2149409034 cites W2019735253 @default.
• W2149409034 cites W2026981776 @default.
• W2149409034 cites W2072684075 @default.
• W2149409034 cites W2075172359 @default.
• W2149409034 cites W2077840753 @default.
• W2149409034 cites W2079185135 @default.
• W2149409034 cites W2096663717 @default.
• W2149409034 cites W2105230577 @default.
• W2149409034 cites W2108019762 @default.
• W2149409034 cites W2116401930 @default.
• W2149409034 cites W2123317844 @default.
• W2149409034 cites W2129040993 @default.
• W2149409034 cites W2132314388 @default.
• W2149409034 cites W2147019299 @default.
• W2149409034 cites W2147132538 @default.
• W2149409034 cites W2151354957 @default.
• W2149409034 cites W2166114264 @default.
• W2149409034 cites W2167623148 @default.
• W2149409034 cites W2917423152 @default.
• W2149409034 doi "https://doi.org/10.2967/jnumed.112.114876" @default.
• W2149409034 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5506835" @default.
• W2149409034 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23651947" @default.
• W2149409034 hasPublicationYear "2013" @default.
• W2149409034 type Work @default.
• W2149409034 sameAs 2149409034 @default.
• W2149409034 citedByCount "28" @default.
• W2149409034 countsByYear W21494090342014 @default.
• W2149409034 countsByYear W21494090342016 @default.
• W2149409034 countsByYear W21494090342017 @default.
• W2149409034 countsByYear W21494090342018 @default.
• W2149409034 countsByYear W21494090342019 @default.
• W2149409034 countsByYear W21494090342020 @default.
• W2149409034 countsByYear W21494090342021 @default.
• W2149409034 countsByYear W21494090342022 @default.
• W2149409034 countsByYear W21494090342023 @default.
• W2149409034 crossrefType "journal-article" @default.
• W2149409034 hasAuthorship W2149409034A5017725276 @default.
• W2149409034 hasAuthorship W2149409034A5018474662 @default.
• W2149409034 hasAuthorship W2149409034A5021531753 @default.
• W2149409034 hasAuthorship W2149409034A5024369884 @default.
• W2149409034 hasAuthorship W2149409034A5048335522 @default.
• W2149409034 hasAuthorship W2149409034A5069167592 @default.
• W2149409034 hasAuthorship W2149409034A5082309424 @default.
• W2149409034 hasAuthorship W2149409034A5086255780 @default.
• W2149409034 hasAuthorship W2149409034A5090922693 @default.
• W2149409034 hasBestOaLocation W21494090341 @default.
• W2149409034 hasConcept C121608353 @default.
• W2149409034 hasConcept C126322002 @default.
• W2149409034 hasConcept C126838900 @default.
• W2149409034 hasConcept C142724271 @default.
• W2149409034 hasConcept C150903083 @default.
• W2149409034 hasConcept C199374082 @default.
• W2149409034 hasConcept C207001950 @default.
• W2149409034 hasConcept C2775842073 @default.
• W2149409034 hasConcept C2989005 @default.
• W2149409034 hasConcept C530470458 @default.
• W2149409034 hasConcept C57742111 @default.
• W2149409034 hasConcept C71924100 @default.
• W2149409034 hasConcept C86803240 @default.
• W2149409034 hasConceptScore W2149409034C121608353 @default.
• W2149409034 hasConceptScore W2149409034C126322002 @default.
• W2149409034 hasConceptScore W2149409034C126838900 @default.
• W2149409034 hasConceptScore W2149409034C142724271 @default.
• W2149409034 hasConceptScore W2149409034C150903083 @default.
• W2149409034 hasConceptScore W2149409034C199374082 @default.
• W2149409034 hasConceptScore W2149409034C207001950 @default.
• W2149409034 hasConceptScore W2149409034C2775842073 @default.
• W2149409034 hasConceptScore W2149409034C2989005 @default.
• W2149409034 hasConceptScore W2149409034C530470458 @default.
• W2149409034 hasConceptScore W2149409034C57742111 @default.
• W2149409034 hasConceptScore W2149409034C71924100 @default.
• W2149409034 hasConceptScore W2149409034C86803240 @default.
• W2149409034 hasIssue "7" @default.
• W2149409034 hasLocation W21494090341 @default.
• W2149409034 hasLocation W21494090342 @default.
• W2149409034 hasLocation W21494090343 @default.

• next