Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149409343> ?p ?o ?g. }
- W2149409343 endingPage "201" @default.
- W2149409343 startingPage "184" @default.
- W2149409343 abstract "Significance: Natural, endogenous electric fields (EFs) and currents arise spontaneously after wounding of many tissues, especially epithelia, and are necessary for normal healing. This wound electrical activity is a long-lasting and regulated response. Enhancing or inhibiting this electrical activity increases or decreases wound healing, respectively. Cells that are responsible for wound closure such as corneal epithelial cells or skin keratinocytes migrate directionally in EFs of physiological magnitude. However, the mechanisms of how the wound electrical response is initiated and regulated remain unclear. Recent Advances: Wound EFs and currents appear to arise by ion channel up-regulation and redistribution, which are perhaps triggered by an intracellular calcium wave or cell depolarization. We discuss the possibility of stimulation of wound healing via pharmacological enhancement of the wound electric signal by stimulation of ion pumping. Critical Issues: Chronic wounds are a major problem in the elderly and diabetic patient. Any strategy to stimulate wound healing in these patients is desirable. Applying electrical stimulation directly is problematic, but pharmacological enhancement of the wound signal may be a promising strategy. Future Directions: Understanding the molecular regulation of wound electric signals may reveal some fundamental mechanisms in wound healing. Manipulating fluxes of ions and electric currents at wounds might offer new approaches to achieve better wound healing and to heal chronic wounds." @default.
- W2149409343 created "2016-06-24" @default.
- W2149409343 creator A5004093071 @default.
- W2149409343 creator A5034132730 @default.
- W2149409343 date "2014-02-01" @default.
- W2149409343 modified "2023-10-13" @default.
- W2149409343 title "The Electrical Response to Injury: Molecular Mechanisms and Wound Healing" @default.
- W2149409343 cites W105346894 @default.
- W2149409343 cites W1496069677 @default.
- W2149409343 cites W1514820219 @default.
- W2149409343 cites W1579089374 @default.
- W2149409343 cites W1963524767 @default.
- W2149409343 cites W1967162280 @default.
- W2149409343 cites W1969870866 @default.
- W2149409343 cites W1975240073 @default.
- W2149409343 cites W1977513995 @default.
- W2149409343 cites W1978609960 @default.
- W2149409343 cites W1980046749 @default.
- W2149409343 cites W1982256640 @default.
- W2149409343 cites W1984671810 @default.
- W2149409343 cites W1990804592 @default.
- W2149409343 cites W1992124749 @default.
- W2149409343 cites W1992354853 @default.
- W2149409343 cites W1994212322 @default.
- W2149409343 cites W1994979040 @default.
- W2149409343 cites W1995899241 @default.
- W2149409343 cites W1996112209 @default.
- W2149409343 cites W1996574729 @default.
- W2149409343 cites W1997703853 @default.
- W2149409343 cites W1999391869 @default.
- W2149409343 cites W2001030445 @default.
- W2149409343 cites W2002222550 @default.
- W2149409343 cites W2009019590 @default.
- W2149409343 cites W2010275145 @default.
- W2149409343 cites W2010446007 @default.
- W2149409343 cites W2011763887 @default.
- W2149409343 cites W2016914234 @default.
- W2149409343 cites W2017872828 @default.
- W2149409343 cites W2019148270 @default.
- W2149409343 cites W2019441990 @default.
- W2149409343 cites W2026671183 @default.
- W2149409343 cites W2028632815 @default.
- W2149409343 cites W2031556847 @default.
- W2149409343 cites W2033631724 @default.
- W2149409343 cites W2035452519 @default.
- W2149409343 cites W2035680453 @default.
- W2149409343 cites W2036816671 @default.
- W2149409343 cites W2037155769 @default.
- W2149409343 cites W2037746979 @default.
- W2149409343 cites W2039743569 @default.
- W2149409343 cites W2039900497 @default.
- W2149409343 cites W2045468939 @default.
- W2149409343 cites W2049270721 @default.
- W2149409343 cites W2050209444 @default.
- W2149409343 cites W2050538885 @default.
- W2149409343 cites W2050762452 @default.
- W2149409343 cites W2051383010 @default.
- W2149409343 cites W2052004855 @default.
- W2149409343 cites W2058365382 @default.
- W2149409343 cites W2058894122 @default.
- W2149409343 cites W2061711390 @default.
- W2149409343 cites W2064069975 @default.
- W2149409343 cites W2067036589 @default.
- W2149409343 cites W2071639338 @default.
- W2149409343 cites W2072982588 @default.
- W2149409343 cites W2073264951 @default.
- W2149409343 cites W2073541331 @default.
- W2149409343 cites W2077102435 @default.
- W2149409343 cites W2079238320 @default.
- W2149409343 cites W2080208447 @default.
- W2149409343 cites W2083364957 @default.
- W2149409343 cites W2084697124 @default.
- W2149409343 cites W2089212821 @default.
- W2149409343 cites W2094897829 @default.
- W2149409343 cites W2095306026 @default.
- W2149409343 cites W2098913470 @default.
- W2149409343 cites W2098952398 @default.
- W2149409343 cites W2101703166 @default.
- W2149409343 cites W2108047477 @default.
- W2149409343 cites W2116568004 @default.
- W2149409343 cites W2118661742 @default.
- W2149409343 cites W2120164109 @default.
- W2149409343 cites W2122735456 @default.
- W2149409343 cites W2124454972 @default.
- W2149409343 cites W2126701927 @default.
- W2149409343 cites W2129745249 @default.
- W2149409343 cites W2130565806 @default.
- W2149409343 cites W2139634320 @default.
- W2149409343 cites W2142830401 @default.
- W2149409343 cites W2143028755 @default.
- W2149409343 cites W2149495388 @default.
- W2149409343 cites W2153500001 @default.
- W2149409343 cites W2157117447 @default.
- W2149409343 cites W2164006488 @default.
- W2149409343 cites W2168283452 @default.
- W2149409343 cites W2171931495 @default.
- W2149409343 cites W2177866586 @default.
- W2149409343 cites W2186116674 @default.