Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149410891> ?p ?o ?g. }
- W2149410891 endingPage "1843.e17" @default.
- W2149410891 startingPage "1843.e9" @default.
- W2149410891 abstract "Alzheimer's disease (AD) and age-related macular degeneration (AMD) are both neurodegenerative disorders which share common pathological and biochemical features of the complement pathway. The aim of this study was to investigate whether there is an association between well replicated AMD genetic risk factors and AD. A large cohort of AD (n = 3898) patients and controls were genotyped for single nucleotide polymorphisms (SNPs) in the complement factor H (CFH), the Age-related maculopathy susceptibility protein 2 (ARMS2) the complement component 2 (C2), the complement factor B (CFB), and the complement component 3 (C3) genes. While significant but modest associations were identified between the complement factor H, the age-related maculopathy susceptibility protein 2, and the complement component 3 single nucleotide polymorphisms and AD, these were different in direction or genetic model to that observed in AMD. In addition the multilocus genetic model that predicts around a half of the sibling risk for AMD does not predict risk for AD. Our study provides further support to the hypothesis that while activation of the alternative complement pathway is central to AMD pathogenesis, it is less involved in AD." @default.
- W2149410891 created "2016-06-24" @default.
- W2149410891 creator A5001679374 @default.
- W2149410891 creator A5002493210 @default.
- W2149410891 creator A5008236816 @default.
- W2149410891 creator A5010807658 @default.
- W2149410891 creator A5011932191 @default.
- W2149410891 creator A5012553649 @default.
- W2149410891 creator A5017384636 @default.
- W2149410891 creator A5017531759 @default.
- W2149410891 creator A5020525495 @default.
- W2149410891 creator A5021970950 @default.
- W2149410891 creator A5026743197 @default.
- W2149410891 creator A5036497300 @default.
- W2149410891 creator A5041419664 @default.
- W2149410891 creator A5050099752 @default.
- W2149410891 creator A5050397593 @default.
- W2149410891 creator A5051833977 @default.
- W2149410891 creator A5058572359 @default.
- W2149410891 creator A5059020388 @default.
- W2149410891 creator A5061616832 @default.
- W2149410891 creator A5062687221 @default.
- W2149410891 creator A5067633738 @default.
- W2149410891 creator A5071373873 @default.
- W2149410891 creator A5076298669 @default.
- W2149410891 creator A5079385332 @default.
- W2149410891 creator A5079862221 @default.
- W2149410891 creator A5085651175 @default.
- W2149410891 date "2012-08-01" @default.
- W2149410891 modified "2023-09-27" @default.
- W2149410891 title "Alzheimer's disease and age-related macular degeneration have different genetic models for complement gene variation" @default.
- W2149410891 cites W1963996422 @default.
- W2149410891 cites W1965395547 @default.
- W2149410891 cites W1965404473 @default.
- W2149410891 cites W1967176607 @default.
- W2149410891 cites W1971882192 @default.
- W2149410891 cites W1977808300 @default.
- W2149410891 cites W1980565738 @default.
- W2149410891 cites W1984944701 @default.
- W2149410891 cites W1990057691 @default.
- W2149410891 cites W1992515694 @default.
- W2149410891 cites W1993044911 @default.
- W2149410891 cites W1993098417 @default.
- W2149410891 cites W1997288094 @default.
- W2149410891 cites W2000399151 @default.
- W2149410891 cites W2003101845 @default.
- W2149410891 cites W2004141045 @default.
- W2149410891 cites W2004377059 @default.
- W2149410891 cites W2007691367 @default.
- W2149410891 cites W2020256864 @default.
- W2149410891 cites W2027707278 @default.
- W2149410891 cites W2029817647 @default.
- W2149410891 cites W2035355245 @default.
- W2149410891 cites W2047219385 @default.
- W2149410891 cites W2075420754 @default.
- W2149410891 cites W2085021795 @default.
- W2149410891 cites W2088551743 @default.
- W2149410891 cites W2100694433 @default.
- W2149410891 cites W2103093164 @default.
- W2149410891 cites W2105479207 @default.
- W2149410891 cites W2108676263 @default.
- W2149410891 cites W2113784410 @default.
- W2149410891 cites W2117386992 @default.
- W2149410891 cites W2117957387 @default.
- W2149410891 cites W2119375868 @default.
- W2149410891 cites W2122743846 @default.
- W2149410891 cites W2127762763 @default.
- W2149410891 cites W2132764626 @default.
- W2149410891 cites W2152119060 @default.
- W2149410891 cites W2156220037 @default.
- W2149410891 cites W2156325413 @default.
- W2149410891 cites W2161633633 @default.
- W2149410891 cites W2164179897 @default.
- W2149410891 cites W2312933856 @default.
- W2149410891 cites W3145351529 @default.
- W2149410891 cites W3214092816 @default.
- W2149410891 doi "https://doi.org/10.1016/j.neurobiolaging.2011.12.036" @default.
- W2149410891 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22300950" @default.
- W2149410891 hasPublicationYear "2012" @default.
- W2149410891 type Work @default.
- W2149410891 sameAs 2149410891 @default.
- W2149410891 citedByCount "23" @default.
- W2149410891 countsByYear W21494108912012 @default.
- W2149410891 countsByYear W21494108912013 @default.
- W2149410891 countsByYear W21494108912014 @default.
- W2149410891 countsByYear W21494108912015 @default.
- W2149410891 countsByYear W21494108912016 @default.
- W2149410891 countsByYear W21494108912017 @default.
- W2149410891 countsByYear W21494108912018 @default.
- W2149410891 countsByYear W21494108912019 @default.
- W2149410891 countsByYear W21494108912020 @default.
- W2149410891 countsByYear W21494108912021 @default.
- W2149410891 countsByYear W21494108912023 @default.
- W2149410891 crossrefType "journal-article" @default.
- W2149410891 hasAuthorship W2149410891A5001679374 @default.
- W2149410891 hasAuthorship W2149410891A5002493210 @default.
- W2149410891 hasAuthorship W2149410891A5008236816 @default.
- W2149410891 hasAuthorship W2149410891A5010807658 @default.