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- W2149418535 abstract "Improvements in the treatment of limited-disease (LD) small cell lung cancer (SCLC) have been substantial due to the introduction of chemotherapy (CHT) consisting of cisplatin (P) and etoposide (E) and the understanding that thoracic radiation therapy (TRT) is an essential component in improving treatment outcome. Also, recent meta-analyses have confirmed the importance of prophylactic cranial irradiation (PCI) in LD SCLC patients who have achieved a complete response to treatment. Optimization of treatment, however, remains a major goal in this disease. TRT/PE/PCI is considered the standard treatment in most centers worldwide, but wide introduction of new and effective third-generation drugs will likely lead to their more frequent testing in the near future in LD SCLC. Optimal dose and fractionation regimens and timing of TRT need further refinements. Twice-daily fractionation is the preferred approach, although it awaits a comparison with high-dose standard TRT. TRT volumes also are an important issue because they will likely relate to the incidence of local failures and toxicity." @default.
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- W2149418535 date "2004-04-01" @default.
- W2149418535 modified "2023-10-16" @default.
- W2149418535 title "Radiation therapy and chemotherapy in the treatment of limited-disease small cell lung cancer" @default.
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- W2149418535 doi "https://doi.org/10.1016/j.hoc.2003.12.009" @default.
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