Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149431363> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2149431363 endingPage "922" @default.
- W2149431363 startingPage "910" @default.
- W2149431363 abstract "Killer T cells with specificity for major histocompatibility antigens have been shown in mice and rats to display idiotypic receptors allowing the lysis of such cells at the effector phase by anti-idiotypic antibodies and complement. A comparison was made between idiotypes displayed by Lyt-1-2+3+ and Lyt-1+2-3- T blasts, generated in the same mixed leucocyte culture (MLC), across an entire H-2 locus barrier. This was done by absorption of anti-idiotypic antibodies with respective T blasts, followed by estimation of the ability of the absorbed antiserum to inhibit MLC or killer T-cell function. Further, the capacity of Lyt-purified, MLC-generated T blasts to provoke specific unresponsiveness via anti-idiotypic immunity in syngeneic recipients was analyzed. Taken together, the results demonstrate that Lyt-1+2-3- T blasts responsible for the major part of MLC proliferation have distincly different idiotypes from those on the Lyt 1-2+3+ killer T cells. That the idiotypes on the killer T-cell presursors can serve as triggering sites for induction of effector T-cell function was then suggested by experiments with Lyt-1-2+3+-purified, normal T cells as precursor cells in vitro. The fact that autoanti-idiotypic antibodies may circumvent the need for helper Lyt-1+2-3- T cells in the generation of allospecific killer T cells indicates that the former cells may normally function partly via such anti-idiotypic reactions." @default.
- W2149431363 created "2016-06-24" @default.
- W2149431363 creator A5026271502 @default.
- W2149431363 creator A5042815651 @default.
- W2149431363 creator A5076373767 @default.
- W2149431363 creator A5090422381 @default.
- W2149431363 date "1979-04-01" @default.
- W2149431363 modified "2023-09-23" @default.
- W2149431363 title "Idiotypic determinants on T-cell subpopulations." @default.
- W2149431363 cites W172399221 @default.
- W2149431363 cites W1964597036 @default.
- W2149431363 cites W1973949275 @default.
- W2149431363 cites W1977904979 @default.
- W2149431363 cites W2005770085 @default.
- W2149431363 cites W2007491896 @default.
- W2149431363 cites W2013227185 @default.
- W2149431363 cites W2026901053 @default.
- W2149431363 cites W2061991278 @default.
- W2149431363 cites W2062743938 @default.
- W2149431363 cites W2066615768 @default.
- W2149431363 cites W2103320120 @default.
- W2149431363 cites W2127814722 @default.
- W2149431363 cites W2146663950 @default.
- W2149431363 cites W2161448672 @default.
- W2149431363 cites W2166529851 @default.
- W2149431363 cites W26895232 @default.
- W2149431363 doi "https://doi.org/10.1084/jem.149.4.910" @default.
- W2149431363 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2184845" @default.
- W2149431363 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/85685" @default.
- W2149431363 hasPublicationYear "1979" @default.
- W2149431363 type Work @default.
- W2149431363 sameAs 2149431363 @default.
- W2149431363 citedByCount "44" @default.
- W2149431363 crossrefType "journal-article" @default.
- W2149431363 hasAuthorship W2149431363A5026271502 @default.
- W2149431363 hasAuthorship W2149431363A5042815651 @default.
- W2149431363 hasAuthorship W2149431363A5076373767 @default.
- W2149431363 hasAuthorship W2149431363A5090422381 @default.
- W2149431363 hasBestOaLocation W21494313631 @default.
- W2149431363 hasConcept C129374314 @default.
- W2149431363 hasConcept C139563560 @default.
- W2149431363 hasConcept C147483822 @default.
- W2149431363 hasConcept C153911025 @default.
- W2149431363 hasConcept C154317977 @default.
- W2149431363 hasConcept C159654299 @default.
- W2149431363 hasConcept C202751555 @default.
- W2149431363 hasConcept C203014093 @default.
- W2149431363 hasConcept C2776090121 @default.
- W2149431363 hasConcept C2910082366 @default.
- W2149431363 hasConcept C542903549 @default.
- W2149431363 hasConcept C54355233 @default.
- W2149431363 hasConcept C67662055 @default.
- W2149431363 hasConcept C74505204 @default.
- W2149431363 hasConcept C86803240 @default.
- W2149431363 hasConcept C8891405 @default.
- W2149431363 hasConceptScore W2149431363C129374314 @default.
- W2149431363 hasConceptScore W2149431363C139563560 @default.
- W2149431363 hasConceptScore W2149431363C147483822 @default.
- W2149431363 hasConceptScore W2149431363C153911025 @default.
- W2149431363 hasConceptScore W2149431363C154317977 @default.
- W2149431363 hasConceptScore W2149431363C159654299 @default.
- W2149431363 hasConceptScore W2149431363C202751555 @default.
- W2149431363 hasConceptScore W2149431363C203014093 @default.
- W2149431363 hasConceptScore W2149431363C2776090121 @default.
- W2149431363 hasConceptScore W2149431363C2910082366 @default.
- W2149431363 hasConceptScore W2149431363C542903549 @default.
- W2149431363 hasConceptScore W2149431363C54355233 @default.
- W2149431363 hasConceptScore W2149431363C67662055 @default.
- W2149431363 hasConceptScore W2149431363C74505204 @default.
- W2149431363 hasConceptScore W2149431363C86803240 @default.
- W2149431363 hasConceptScore W2149431363C8891405 @default.
- W2149431363 hasIssue "4" @default.
- W2149431363 hasLocation W21494313631 @default.
- W2149431363 hasLocation W21494313632 @default.
- W2149431363 hasLocation W21494313633 @default.
- W2149431363 hasLocation W21494313634 @default.
- W2149431363 hasOpenAccess W2149431363 @default.
- W2149431363 hasPrimaryLocation W21494313631 @default.
- W2149431363 hasRelatedWork W1570691765 @default.
- W2149431363 hasRelatedWork W1830230921 @default.
- W2149431363 hasRelatedWork W1991655492 @default.
- W2149431363 hasRelatedWork W2002809032 @default.
- W2149431363 hasRelatedWork W2024292761 @default.
- W2149431363 hasRelatedWork W2040729254 @default.
- W2149431363 hasRelatedWork W2139860153 @default.
- W2149431363 hasRelatedWork W2337910591 @default.
- W2149431363 hasRelatedWork W2400126894 @default.
- W2149431363 hasRelatedWork W4307359798 @default.
- W2149431363 hasVolume "149" @default.
- W2149431363 isParatext "false" @default.
- W2149431363 isRetracted "false" @default.
- W2149431363 magId "2149431363" @default.
- W2149431363 workType "article" @default.